Rabbit anti-Rat Prostaglandin Transporter Polyclonal Antibody | anti-SLCO2A1 antibody

Prostaglandin Transporter (PGT)

Cat. Num. AAA613024

• Gene Names: SLCO2A1; PGT; MATR1; OATP2A1; SLC21A2
• Reactivity: Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Prostaglandin Transporter; Polyclonal Antibody; Prostaglandin Transporter (PGT); Anti -Prostaglandin Transporter (PGT); anti-SLCO2A1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat Prostaglandin Transporter (PGT). No significant sequence homology is detected with other oatp1-3, OATP or LST-1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.

• Applicable Applications for anti-SLCO2A1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunohistochemistry and Western Blot.; Dilution: Western Blot: 1-10ug/ml using ECL.; ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml.; Immunohistochemistry: 2-20ug/ml in paraformaldehyde fixed tissue sections.
• Immunogen: A 20 AA synthetic peptide sequence near the C-terminus of rat PGT (KLH). Species sequence homology: human-60%.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLCO2A1 antibody

Prostaglandins (PGs) are signalling molecules that modulate physiological or pathologic functions such as platelet aggregation, vascular tone, gastric cytoprotection, uterine contraction, inflammatory responses, cancer, and Alzheimer's Disease.

Product Categories/Family for anti-SLCO2A1 antibody

Antibodies; Abs to Prostaglandins

NCBI and Uniprot Product Information

• NCBI GI #: 3676522
• NCBI GeneID: 6578
• UniProt Accession #: Q92959; Q86V98; Q8IUN2; Q4LEJ8; Q4LEJ9
• Molecular Weight: 70,044 Da
• NCBI Official Full Name: prostaglandin transporter
• NCBI Official Synonym Full Names: solute carrier organic anion transporter family, member 2A1
• NCBI Official Symbol: SLCO2A1
• NCBI Official Synonym Symbols: PGT; MATR1; OATP2A1; SLC21A2
• NCBI Protein Information: solute carrier organic anion transporter family member 2A1; matrin F/G 1; OTTHUMP00000216361; OTTHUMP00000216362; OTTHUMP00000216363; prostaglandin transporter; solute carrier family 21 member 2; solute carrier family 21 (prostaglandin transporter), member 2
• UniProt Protein Name: Solute carrier organic anion transporter family member 2A1
• Protein Family: Solute carrier organic anion transporter family
• UniProt Gene Name: SLCO2A1
• UniProt Synonym Gene Names: OATP2A1; SLC21A2
• UniProt Entry Name: SO2A1_HUMAN

NCBI Description

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

Uniprot Description

SLCO2A1: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. Defects in SLCO2A1 are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 2 (PHOAR2). PHOAR2 is a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Belongs to the organo anion transporter (TC 2.A.60) family.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: lipid transporter activity; prostaglandin transmembrane transporter activity

Biological Process: prostaglandin transport; sodium-independent organic anion transport; lipid transport; transmembrane transport

Disease: Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2