Mouse anti-Human Fatty Acid Binding Protein Monoclonal Antibody | anti-H-FABP antibody

Fatty Acid Binding Protein, Heart (Heart-type Fatty Acid-binding Protein, H-FABP, Fatty Acid Binding Protein 3, FABP3, FABP11, Mammary-derived Growth Inhibitor, MDGI, Muscle Fatty Acid Binding Protein, M-FABP, O-FABP) (PE)

Cat. Num. AAA6129248

• Gene Names: FABP3; MDGI; FABP11; H-FABP; M-FABP; O-FABP
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography
• Synonyms: Fatty Acid Binding Protein; Monoclonal Antibody; Heart (Heart-type Fatty Acid-binding Protein; H-FABP; Fatty Acid Binding Protein 3; FABP3; FABP11; Mammary-derived Growth Inhibitor; MDGI; Muscle Fatty Acid Binding Protein; M-FABP; O-FABP) (PE); anti-H-FABP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 12H23
• Specificity: Recognizes human heart FABP.
• Purity/Purification: Purified by Protein A Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-H-FABP antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Human heart FABP
• Conjugate: PE
• Hybridoma: Sp2/0 myeloma cells with spleen cells from BALB/c mice.
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-H-FABP antibody

H-FABP is also known as heart type fatty-acid binding protein, and FABP3. H-FABP belongs to the FABP family, and is a 14kD cytosolic non-enzymatic protein involved in the uptake, transport and metabolism of fatty acids. H-FABP also has a role in cell proliferation and is a candidate tumor suppressor gene in breast cancer. H-FABP was initially purified from the heart muscle, but has since been found to have a widespread tissue distribution, with highest concentration in cardiac and skeletal muscle. H-FABP has been implicated in neurodegenerative disorders, including Down syndrome and Alzheimer's disease, and is a specific and sensitive biomarker for acute myocardial infarctions.

Product Categories/Family for anti-H-FABP antibody

Antibodies; Fatty Acid Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 119802
• NCBI GeneID: 2170
• UniProt Accession #: P05413; Q5VV93; Q99957; B2RAB6
• Molecular Weight: 133
• NCBI Official Full Name: Fatty acid-binding protein, heart
• NCBI Official Synonym Full Names: fatty acid binding protein 3, muscle and heart
• NCBI Official Symbol: FABP3
• NCBI Official Synonym Symbols: MDGI; FABP11; H-FABP; M-FABP; O-FABP
• NCBI Protein Information: fatty acid-binding protein, heart; fatty acid binding protein 11; mammary-derived growth inhibitor; muscle fatty acid-binding protein; Fatty acid-binding protein 3, muscle; heart-type fatty acid-binding protein
• UniProt Protein Name: Fatty acid-binding protein, heart
• Protein Family: Fatty acid binding protein
• UniProt Gene Name: FABP3
• UniProt Synonym Gene Names: FABP11; MDGI; H-FABP; MDGI; M-FABP
• UniProt Entry Name: FABPH_HUMAN

NCBI Description

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

FABP3: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; sarcoplasm; cytosol

Molecular Function: protein binding; icosatetraenoic acid binding; cytoskeletal protein binding; long-chain fatty acid transporter activity

Biological Process: response to drug; negative regulation of cell proliferation; cholesterol homeostasis; regulation of fatty acid oxidation; fatty acid metabolic process; response to insulin stimulus; phospholipid homeostasis