Rabbit anti-Rat Cav2.3 Polyclonal Antibody | anti-Cacna1e antibody
Cav2.3 (R-Type of Voltage-gated Calcium Channel, Cacna1e)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: Rat brain membranes (1:200).
Immunohistochemistry: Rat brain sections.
NCBI and Uniprot Product Information
NCBI Description
T-type low voltage-activated calcium channel that may be involved in neuronal firing [RGD, Feb 2006]
Uniprot Description
CACNA1E: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium
Cellular Component: voltage-gated calcium channel complex; perikaryon
Molecular Function: voltage-gated calcium channel activity; low voltage-gated calcium channel activity; high voltage-gated calcium channel activity; protein N-terminus binding; calcium ion binding
Biological Process: fear response; behavioral fear response; regulation of heart rate; response to pain; transmission of nerve impulse; locomotory behavior; sensory perception of pain; glucose homeostasis; neurological system process; synaptic transmission; sperm motility; behavioral response to pain; calcium ion transport; visual learning
Research Articles on Cacna1e
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Product Notes
The Cacna1e cacna1e (Catalog #AAA612325) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cav2.3 (R-Type of Voltage-gated Calcium Channel, Cacna1e) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cav2.3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: Rat brain membranes (1:200). Immunohistochemistry: Rat brain sections. Researchers should empirically determine the suitability of the Cacna1e cacna1e for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cav2.3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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