Goat anti-Human CCR11 Polyclonal Antibody | anti-CCRL1 antibody

CCR11 (Chemokine Receptor 11, CKRB)

Cat. Num. AAA611786

• Gene Names: CCRL1; PPR1; CCBP2; CCR10; CCR11; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified by affinity chromatography
• Synonyms: CCR11; Polyclonal Antibody; CCR11 (Chemokine Receptor 11; CKRB); Anti -CCR11 (Chemokine Receptor 11; anti-CCRL1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CCR11. Peptide sequence is < 50% identical to other human chemokine receptors in this region. Species Crossreactivity: mouse
• Purity/Purification: Purified by affinity chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CCRL1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:37,500; Western Blot: 1:500; Immunohistochemistry (Paraffin): 1:125; Optimal dilution determined by the researcher.
• Immunogen: Synthetic peptide corresponding to aa4-31, EQNQSTDYYYEENEMNGTYDYSQYELIC, of human CCR11
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin section mouse lung staining)

Related Product Information for anti-CCRL1 antibody

Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

CCR11 is a G protein-coupled, seven-transmembrane receptor protein that plays a role in the chemotaxis and trafficking of leukocytes. Showing similar binding affinities as does CCR2 and CCR10 (1,2), CCR11 has been shown to specifically bind the MCP- (monocyte chemoattractant protein) family of chemokines, including MCP-4, MCP-2, and MCP-1. It was also shown to bind eotaxin (3). Though CCR11 shares functional similarity to CCR2 because it recognizes members of the MCP family, CCR11 has a distinct expression pattern (3).

Product Categories/Family for anti-CCRL1 antibody

Antibodies; Abs to G Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 30795217
• NCBI GeneID: 51554
• NCBI Accession #: NP_848540.1
• NCBI GenBank Nucleotide #: NM_178445.1
• UniProt Accession #: Q9NPB9; B2R9U7; Q4VBN4
• NCBI Official Full Name: C-C chemokine receptor type 11
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor-like 1
• NCBI Official Symbol: CCRL1
• NCBI Official Synonym Symbols: PPR1; CCBP2; CCR10; CCR11; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
• NCBI Protein Information: C-C chemokine receptor type 11; C-C CKR-11; OTTHUMP00000216426; CC chemokine receptor-like 1; chemocentryx chemokine receptor; chemokine, cc motif, receptor-like protein 1; orphan seven-transmembrane receptor, chemokine related
• UniProt Protein Name: C-C chemokine receptor type 11
• UniProt Gene Name: CCRL1
• UniProt Synonym Gene Names: CCBP2; CCR11; VSHK1
• UniProt Entry Name: CCRL1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]

Uniprot Description

CCRL1: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane

Molecular Function: protein binding; chemokine binding; chemokine receptor activity; scavenger receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; immune response; chemotaxis