Rabbit anti-Human FOXE3 Polyclonal Antibody | anti-FOXE3 antibody

FOXE3 (Forkhead Box E3, Drosphilia Forkhead Homolog Like 12, FKHL12, Forkhead Related Activator 8, FREAC8)

Cat. Num. AAA611199

• Gene Names: FOXE3; FKHL12; FREAC8
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXE3; Polyclonal Antibody; FOXE3 (Forkhead Box E3; Drosphilia Forkhead Homolog Like 12; FKHL12; Forkhead Related Activator 8; FREAC8); Anti -FOXE3 (Forkhead Box E3; anti-FOXE3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXE3.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-FOXE3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA Titer: 1:250,000.; Western Blot: 1ug/ml. Band detected at 34 (light) and 15kD using HepG2 cells.
• Immunogen: Synthetic peptide (C-ASPPLYSQVPDRLVL) corresponding to human FOXE3 (KLH). Molecular Weight: 33.3kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-FOXE3 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 11386197
• NCBI GeneID: 2301
• NCBI Accession #: NP_036318.1
• NCBI GenBank Nucleotide #: NM_012186.2
• UniProt Accession #: Q13461; Q5SVY9; Q9NQV9
• Molecular Weight: 33,234 Da
• NCBI Official Full Name: forkhead box protein E3
• NCBI Official Synonym Full Names: forkhead box E3
• NCBI Official Symbol: FOXE3
• NCBI Official Synonym Symbols: FKHL12; FREAC8
• NCBI Protein Information: forkhead box protein E3; FREAC-8; OTTHUMP00000009657; forkhead-related protein FKHL12; forkhead, drosophila, homolog-like 12; forkhead-related transcription factor 8
• UniProt Protein Name: Forkhead box protein E3
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXE3
• UniProt Synonym Gene Names: FKHL12; FREAC8
• UniProt Entry Name: FOXE3_HUMAN

NCBI Description

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq]

Uniprot Description

FOXE3: Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD); also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. Defects in FOXE3 are a cause of congenital primary aphakia (CPA). Aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: transcription factor complex; nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; camera-type eye development; cell development; positive regulation of epithelial cell proliferation

Disease: Anterior Segment Mesenchymal Dysgenesis; Aphakia, Congenital Primary