Rabbit anti-Rat Calcitonin Receptor Like Receptor Polyclonal Antibody | anti-CALCRL antibody
Calcitonin Receptor Like Receptor (CRLR)
Gene Names
CALCRL; CRLR; CGRPR
Reactivity
Rat
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
Calcitonin Receptor Like Receptor; Polyclonal Antibody; Calcitonin Receptor Like Receptor (CRLR); Anti -Calcitonin Receptor Like Receptor (CRLR); anti-CALCRL antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat Calcitonin Receptor Like Receptor. No significant sequence homology is detected with other CRLR. Species sequence homology
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a liquid in PBS, 40% glycerol.
Applicable Applications for anti-CALCRL antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat plates at 1ug/ml.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat plates at 1ug/ml.
Immunogen
Synthetic peptide consisting of 20aa mapping near the cytoplasmic, C-terminus of rat CRLR (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CALCRL antibody
The calcitonin family peptides probably act through G-protein coupled membrane receptors. The gene for calcitonin receptors has been cloned. It is homologous to GPCRs in family "B" which typically recognizes regulatory peptides (secretin, glucagons, VIP). Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461aa; rat/mouse 463aa) was identified. CRLR has 55% homology with calcitonin receptor. It is now shown that CRLR can function as either a CGRP receptor or an ADM receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed. RAMPs1-3 contains an N-terminal signal peptide, an extracellular N-terminus, a single transmembrane domain near the C-terminus, and cytoplasmic C-terminus. RAMP1-3 displays 31% identity. RAMPS may be involved in the transport of CRLR to the plasma membrane. RAMP1 (human, mouse, rat 148 aa) presents the CRLR receptor as a glycoprotein that function as CGRP receptor. RAMP1 is expressed in many tissues, including the uterus, bladder, brain, pancreas, and GI tract. CRLR and RAMP1 are not co-expressed in all tissues suggesting that their co-expression may define which cells express functional CGRP receptors. RAMP2 (human 175aa; rat 182aa, and mouse 189 aa)-transported receptors are core-glycosylated and function as ADM receptor. It is expressed in the lung, breast, immune system and fetal tissues. RAMP3 is most abundant in the kidney and lung.
Product Categories/Family for anti-CALCRL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52,929 Da
NCBI Official Full Name
calcitonin gene-related peptide type 1 receptor
NCBI Official Synonym Full Names
calcitonin receptor-like
NCBI Official Symbol
CALCRL
NCBI Official Synonym Symbols
CRLR; CGRPR
NCBI Protein Information
calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor
UniProt Protein Name
Calcitonin gene-related peptide type 1 receptor
Protein Family
UniProt Gene Name
CALCRL
UniProt Synonym Gene Names
CGRPR; CGRP type 1 receptor
UniProt Entry Name
CALRL_HUMAN
Uniprot Description
CALCRL: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Cell cycle regulation; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component: endoplasmic reticulum; lysosome; integral to plasma membrane; plasma membrane; endosome
Molecular Function: G-protein coupled receptor activity; protein binding; calcitonin gene-related polypeptide receptor activity; adrenomedullin receptor activity; protein transporter activity; calcitonin receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; protein transport; regulation of muscle contraction; negative regulation of inflammatory response; positive regulation of smooth muscle cell proliferation; heart development; calcium ion transport; receptor internalization; positive regulation of cAMP biosynthetic process; cAMP biosynthetic process; angiogenesis; G-protein signaling, adenylate cyclase activating pathway
Research Articles on CALCRL
Similar Products
Product Notes
The CALCRL calcrl (Catalog #AAA611175) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Calcitonin Receptor Like Receptor (CRLR) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Calcitonin Receptor Like Receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1000-1:5000 (ECL). ELISA: 1:10,000-1:50,000. Control peptide can be used to coat plates at 1ug/ml. Researchers should empirically determine the suitability of the CALCRL calcrl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcitonin Receptor Like Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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