Rat anti-Human, Mouse Delangin, Isoform A Monoclonal Antibody | anti-Nipbl antibody

Delangin, Isoform A (Nipped-B-like Protein, Delangin, SCC2 Homolog, NIPBL, IDN3)

Cat. Num. AAA609829

• Gene Names: Nipbl; Idn3; C79399; 4921518A06Rik; 4933421G18Rik
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Delangin; Isoform A; Monoclonal Antibody; Isoform A (Nipped-B-like Protein; SCC2 Homolog; NIPBL; IDN3); Anti -Delangin; anti-Nipbl antibody

• Host: Rat
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10K293
• Specificity: Recognizes human Delangin Isoform A (long form).
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-Nipbl antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence.; Dilution: Western Blot: 1ug/ml; Immunohistochemistry: 10ug/ml; Immunofluorescence: 10ug/ml; Immunoprecipitation: 2ug/ml
• Immunogen: Delangin peptide conjugated to a carrier protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Nipbl antibody

The NIPBL gene provides instructions for making a protein called delangin that plays an important role in human development. Before birth, delangin is found in the developing limbs, the bones of the skull and face, the spinal column, the heart, and other parts of the body. One of the functions of delangin is to help control the activity of chromosomes during cell division. Before cells divide, they must copy all of their chromosomes. The copied DNA from each chromosome is arranged into two identical structures, called sister chromatids. The sister chromatids are attached to one another during the early stages of cell division by a group of proteins known as the cohesion complex. Delangin controls the interaction between the cohesion complex and the DNA that makes up the sister chromatids. Additionally, delangin regulates the activity of certain genes that are critical for normal development, particularly genes that coordinate the development of tissues that will become the limbs and face. Studies suggest that delangin is also involved in the repair of damaged DNA.

Product Categories/Family for anti-Nipbl antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 229442423
• NCBI GeneID: 71175
• UniProt Accession #: Q6KCD5; Q6KC78; Q7TNS4; Q8BKV4; Q8CES9; Q9CUC6
• Molecular Weight: 315,450 Da
• NCBI Official Full Name: delangin isoform B
• NCBI Official Synonym Full Names: Nipped-B homolog (Drosophila)
• NCBI Official Symbol: Nipbl
• NCBI Official Synonym Symbols: Idn3; C79399; 4921518A06Rik; 4933421G18Rik
• NCBI Protein Information: nipped-B-like protein; SCC2 homolog; delangin homolog
• UniProt Protein Name: Nipped-B-like protein
• Protein Family: Nipped-B-like protein
• UniProt Gene Name: Nipbl
• UniProt Entry Name: NIPBL_MOUSE

Uniprot Description

NIPBL: a chromatin protein involved in sister chromatid cohesion. Interacts directly with CBX5 via the PxVxL motif, which is required for interaction with chromoshadow domains. Defects in NIPBL are the cause of Cornelia de Lange syndrome (CDL). CDL is a dominantly inherited multisystem developmental disorder. Three alternatively spliced isoforms have been reported.

Protein type: DNA-binding

Cellular Component: nucleus; chromatin

Molecular Function: protein C-terminus binding; histone deacetylase binding; protein N-terminus binding; chromatin binding

Biological Process: heart morphogenesis; fat cell differentiation; embryonic forelimb morphogenesis; developmental growth; heart development; regulation of embryonic development; mitotic sister chromatid cohesion; positive regulation of multicellular organism growth; ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; forelimb morphogenesis; positive regulation of histone deacetylation; sensory perception of sound; embryonic digestive tract morphogenesis; regulation of hair cycle; eye morphogenesis; regulation of developmental growth; external genitalia morphogenesis; stem cell maintenance; embryonic cranial skeleton morphogenesis; embryonic viscerocranium morphogenesis; cell cycle; positive regulation of ossification; maintenance of mitotic sister chromatid cohesion; positive regulation of transcription from RNA polymerase II promoter; brain development; cognition; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus