Mouse CD91, 85kD Monoclonal Antibody
CD91, 85kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)
Reactivity
Human, Mouse, Rabbit
Applications
Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
PurifiedAscites
Synonyms
CD91; 85kD; Monoclonal Antibody; 85kD (LRP; alpha2MR; Low Density Lipoprotein Receptor-related Protein); Anti -CD91; anti-CD91; 85kD antibody
Host
Mouse
Reactivity
Human, Mouse, Rabbit
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9L778
Specificity
Recognizes human 85kD low density LRP. Species Crossreactivity: mouse, rabbit.
Purity/Purification
Purified
Ascites
Ascites
Form/Format
Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, pH 6.6.
Applicable Applications for anti-CD91, 85kD antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry.
Dilution: Western Blot: 1-5ug/ml
Immunohistochemistry: 1-10ug/ml
Dilution: Western Blot: 1-5ug/ml
Immunohistochemistry: 1-10ug/ml
Immunogen
Human 85kD low density LRP.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CD91, 85kD antibody
CD91, also known as a2-macroglobulin receptor (a2MR), apolipoprotein E receptor (ApoER) and low density lipoprotein receptor-related protein (LRP), is a large two-chain membrane protein that binds the proteinase-activated form of the plasma membrane protein a2M.1 a2M is a proteinase-inhibitor containing a region that is a substrate for a wide range of proteinases including trypsin, chymotrypsin, plasmin, neutrophil elastase and fibroblast collagenase.1 Binding of a2M:proteinase complexes to a2MR is followed by endocytosis and degradation of the ligand in lysosomes.
CD91 consists of two non-covalently associated polypeptides of ~420 to ~85kD, and has been shown to be present in a restricted spectrum of cell types, including neurons and astrocytes in the central nervous system, epithelial cells in the gastrointestinal tract, smooth muscle cells, fibroblasts, Leydig cells in testis, granulose cells in ovary, and dendritic interstitial cells of kidney.1 The high abundance of CD91 in certain cells types of most organs suggest two different mechanisms of CD91-mediated ligand clearance.1 CD91 is expressed on malignant cells from patients with acute and chronic myelomonocytic leukemia, while no significant expression was found on malignant cells from acute and chronic lymphatic leukemia, lymphomas, plasma cell leukemias or hairy cell leukemia. CD91 was also shown to have a close correlation with CD14 surface expression.
CD91 consists of two non-covalently associated polypeptides of ~420 to ~85kD, and has been shown to be present in a restricted spectrum of cell types, including neurons and astrocytes in the central nervous system, epithelial cells in the gastrointestinal tract, smooth muscle cells, fibroblasts, Leydig cells in testis, granulose cells in ovary, and dendritic interstitial cells of kidney.1 The high abundance of CD91 in certain cells types of most organs suggest two different mechanisms of CD91-mediated ligand clearance.1 CD91 is expressed on malignant cells from patients with acute and chronic myelomonocytic leukemia, while no significant expression was found on malignant cells from acute and chronic lymphatic leukemia, lymphomas, plasma cell leukemias or hairy cell leukemia. CD91 was also shown to have a close correlation with CD14 surface expression.
Product Categories/Family for anti-CD91, 85kD antibody
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Product Notes
The CD91, 85kD (Catalog #AAA608085) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD91, 85kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein) reacts with Human, Mouse, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's CD91, 85kD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Dilution: Western Blot: 1-5ug/ml Immunohistochemistry: 1-10ug/ml. Researchers should empirically determine the suitability of the CD91, 85kD for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD91, 85kD, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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