Mouse Troponin I, Cardiac/Skeletal Monoclonal Antibody | anti-TNNC1 antibody

Troponin I, Cardiac/Skeletal (Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1/Troponin I, slow skeletal muscle, Troponin I, slow-twitch isoform, TNNI1/Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2)

Cat. Num. AAA606408

• Gene Names: TNNC1; TNC; TN-C; TNNC; CMD1Z; CMH13
• Reactivity: Bovine, Canine, Feline, Goat, Human, Mouse, Porcine, Rabbit, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Troponin I; Cardiac/Skeletal; Monoclonal Antibody; Cardiac/Skeletal (Troponin I; cardiac muscle; Cardiac troponin I; TNNI3; TNNC1/Troponin I; slow skeletal muscle; slow-twitch isoform; TNNI1/Troponin I; fast skeletal muscle; fast-twitch isoform; TNNI2); Anti -Troponin I; anti-TNNC1 antibody

• Host: Mouse
• Reactivity: Bovine, Canine, Feline, Goat, Human, Mouse, Porcine, Rabbit, Rat
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 10F565
• Specificity: Recognizes cardiac and skeletal human troponin I. It is specific for an epitope between aa186-192 of cardiac troponin I.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-TNNC1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Free human cardiac troponin I
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-TNNC1 antibody

Troponin I is 1 of 3 subunits that constitute the troponin complex which plays an important role in the regulation of skeletal and cardiac muscle contraction. It is presented in cardiac tissue by a single isoform with a molecular weight of 29kD and is known as a specific marker for cardiac tissue damage.

Product Categories/Family for anti-TNNC1 antibody

Antibodies; Abs to Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 4507615
• NCBI GeneID: 7134
• NCBI Accession #: NP_003271.1
• NCBI GenBank Nucleotide #: NM_003280.2
• UniProt Accession #: P63316; O14800; P02590; P04463
• Molecular Weight: 18,403 Da
• NCBI Official Full Name: troponin C, slow skeletal and cardiac muscles
• NCBI Official Synonym Full Names: troponin C type 1 (slow)
• NCBI Official Symbol: TNNC1
• NCBI Official Synonym Symbols: TNC; TN-C; TNNC; CMD1Z; CMH13
• NCBI Protein Information: troponin C, slow skeletal and cardiac muscles; troponin C1, slow; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C
• UniProt Protein Name: Troponin C, slow skeletal and cardiac muscles
• Protein Family: Troponin
• UniProt Gene Name: TNNC1
• UniProt Synonym Gene Names: TNNC; TN-C
• UniProt Entry Name: TNNC1_HUMAN

NCBI Description

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Uniprot Description

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.

Protein type: Motility/polarity/chemotaxis; Calcium-binding

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; troponin T binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding

Biological Process: response to metal ion; regulation of ATPase activity; regulation of muscle contraction; diaphragm contraction; regulation of muscle filament sliding speed; ventricular cardiac muscle morphogenesis; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13