Mouse Hematopoietically Expressed Homeobox Monoclonal Antibody | anti-HHEX antibody

Hematopoietically Expressed Homeobox (HEX, HHEX, HMPH, HOX11L-PEN, PRH)

Cat. Num. AAA603926

• Gene Names: HHEX; HEX; PRH; HMPH; PRHX; HOX11L-PEN
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Hematopoietically Expressed Homeobox; Monoclonal Antibody; Hematopoietically Expressed Homeobox (HEX; HHEX; HMPH; HOX11L-PEN; PRH); Anti -Hematopoietically Expressed Homeobox (HEX; anti-HHEX antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C175
• Specificity: Recognizes human Hematopoietically Expressed Homeobox.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-HHEX antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human Hematopoietically Expressed Homeobox
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-HHEX antibody

Antibodies; Abs to Homeobox (HOX)

NCBI and Uniprot Product Information

• NCBI GI #: 30048159
• NCBI GeneID: 3087
• UniProt Accession #: Q03014; Q96CE9; Q9C057
• Molecular Weight: 30,022 Da
• NCBI Official Full Name: Hematopoietically expressed homeobox
• NCBI Official Synonym Full Names: hematopoietically expressed homeobox
• NCBI Official Symbol: HHEX
• NCBI Official Synonym Symbols: HEX; PRH; HMPH; PRHX; HOX11L-PEN
• NCBI Protein Information: hematopoietically-expressed homeobox protein HHEX; OTTHUMP00000020100; homeobox protein HEX; homeobox protein PRH; homeobox, hematopoietically expressed; proline-rich homeodomain-containing transcription factor
• UniProt Protein Name: Hematopoietically-expressed homeobox protein HHEX
• Protein Family: Hematopoietically-expressed homeobox protein
• UniProt Gene Name: HHEX
• UniProt Synonym Gene Names: HEX; PRH; PRHX
• UniProt Entry Name: HHEX_HUMAN

NCBI Description

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq]

Uniprot Description

HHEX: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; TATA-binding protein binding; sequence-specific DNA binding; eukaryotic initiation factor 4E binding; chromatin binding; DNA bending activity; transcription factor binding

Biological Process: response to peptide hormone stimulus; negative regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; poly(A)+ mRNA export from nucleus; pancreas development; response to wounding; thyroid gland development; cell differentiation; vasculogenesis; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; multicellular organism growth; negative regulation of cyclin-dependent protein kinase activity; forebrain morphogenesis; interkinetic nuclear migration; regulation of cell proliferation; cell proliferation; mRNA export from nucleus; negative regulation of angiogenesis; B cell differentiation; myeloid leukocyte differentiation; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; endoderm development