Mouse anti-Human IRTA5 Monoclonal Antibody | anti-FCRL1 antibody
IRTA5 (Immunoglobulin Superfamily Receptor Translocation Associated 5, FcRH1) (APC)
Gene Names
FCRL1; FCRH1; IFGP1; IRTA5; DKFZp667O1421; FCRL1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
PurifiedPurified immunoglobulin
Synonyms
IRTA5; Monoclonal Antibody; IRTA5 (Immunoglobulin Superfamily Receptor Translocation Associated 5; FcRH1) (APC); Anti -IRTA5 (Immunoglobulin Superfamily Receptor Translocation Associated 5; anti-FCRL1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7H13
Specificity
Recognizes human FcRH1/IRTA5.
Purity/Purification
Purified
Purified immunoglobulin
Purified immunoglobulin
Form/Format
Supplied as a liquid in PBS. Conjugated to APC.
Applicable Applications for anti-FCRL1 antibody
Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry.
Immunogen
Human FcRH1/IRTA5
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Related Product Information for anti-FCRL1 antibody
FcRH1, also known as IRTA5 (Immunoglobulin superfamily Receptor Translocation Associated 5), is a type I transmembrane protein having three extracellular Ig-like domains and cytoplasmic ITAM-like motifs. The FcRH subfamily shares sequence homology with the classical receptors for Ig, and the corresponding genes are localized to human chromosome Iq21-23, a hotspot for translocation events involved in B-cell malignancy. FcRH1 is expressed primarily in B cells.
Product Categories/Family for anti-FCRL1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
46,936 Da
NCBI Official Full Name
immunoglobulin superfamily receptor translocation associated 5
NCBI Official Synonym Full Names
Fc receptor-like 1
NCBI Official Symbol
FCRL1
NCBI Official Synonym Symbols
FCRH1; IFGP1; IRTA5; DKFZp667O1421; FCRL1
NCBI Protein Information
Fc receptor-like protein 1; hIFGP1; fcR-like protein 1; IFGP family protein 1; fc receptor homolog 1; immunoglobulin superfamily Fc receptor, gp42; immune receptor translocation-associated protein 5
UniProt Protein Name
Fc receptor-like protein 1
Protein Family
UniProt Gene Name
FCRL1
UniProt Synonym Gene Names
FCRH1; IFGP1; IRTA5
UniProt Entry Name
FCRL1_HUMAN
NCBI Description
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Uniprot Description
FCRL1: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: plasma membrane; integral to membrane
Research Articles on FCRL1
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
2. Observational study of gene-disease association. (HuGE Navigator)
3. Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia.
4. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
5. FcRH1 thus has the potential to serve as an activating coreceptor on B cells.
2. Observational study of gene-disease association. (HuGE Navigator)
3. Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia.
4. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
5. FcRH1 thus has the potential to serve as an activating coreceptor on B cells.
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Product Notes
The FCRL1 fcrl1 (Catalog #AAA603551) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IRTA5 (Immunoglobulin Superfamily Receptor Translocation Associated 5, FcRH1) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IRTA5 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Researchers should empirically determine the suitability of the FCRL1 fcrl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRTA5, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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