Mouse anti-Human RAD18 Monoclonal Antibody | anti-RAD18 antibody
RAD18 (hHR18, hRAD18, Postreplication Repair Protein hRAD18p, Postreplication Repair Protein RAD18, RAD18 Homolog, RAD18 (S. cerevisiae) Homolog, RING Finger Protein 73, RNF73)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq]
Uniprot Description
RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.
Protein type: Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; DNA repair, damage
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: XY body; replication fork; nucleus; chromatin
Molecular Function: Y-form DNA binding; protein binding; zinc ion binding; ubiquitin protein ligase binding; damaged DNA binding; polyubiquitin binding; ligase activity
Biological Process: negative regulation of DNA recombination; protein ubiquitination; spermatogenesis; DNA repair; response to UV
Research Articles on RAD18
2. Data show that that WRNIP1 interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA.
3. Data indicate RAD18 as a key factor that orchestrates HRR through surveillance of the DNA damage signal.
4. epair of induced and spontaneous DSBs that accumulate RAD18 and RAD51 in G1 phase cells is delayed until S phase.
5. A model in which RAD18 within damage-induced nuclear foci is immobilized and is required for recruitment of Y-family DNA polymerases and subsequent mutagenesis.
6. RAD18 Arg302Gln polymorphism is associated with non-small-cell lung cancer
7. The SAP domain of RAD18 (residues 248-282) is crucial for binding of RAD18 complexed with RAD6B to DNA substrates.
8. RAD18 signals DNA polymerase IOTA to stalled replication forks in cells entering S phase with DNA damage.
9. Observational study of gene-disease association. (HuGE Navigator)
10. Single nucleotide polymorphism in the RAD18 gene is associated with colorectal cancer
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Product Notes
The RAD18 (Catalog #AAA602806) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The RAD18 (hHR18, hRAD18, Postreplication Repair Protein hRAD18p, Postreplication Repair Protein RAD18, RAD18 Homolog, RAD18 (S. cerevisiae) Homolog, RING Finger Protein 73, RNF73) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAD18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the RAD18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAD18, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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