anti-Human Tankyrase Monoclonal Antibody | anti-tankyrase antibody

Anti - Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase)

Cat. Num. AAA600850

• Gene Names: tankyrase; BcDNA:LD22548; CG17487; CG4719; DmelCG4719
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by immunoaffinity chromatography.
• Synonyms: Tankyrase; Monoclonal Antibody; Anti - Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase); Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase); anti-tankyrase antibody

• Host: Host: Mouse; Source: Human
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 7C48
• Specificity: Detects human TANK protein.
• Purity/Purification: Purified by immunoaffinity chromatography.
• Form/Format: Affinity Purified; Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, before the addition of glycerol to 40%.
• Concentration: ~1mg/ml (varies by lot)
• Sequence Length: 1181

• Applicable Applications for anti-tankyrase antibody: ELISA, Western Blot
• Application Notes: Suitable for use in Western Blot and ELISA. Other applications not tested.; Dilution: Western Blot: 1-5ug/ml using ECL technique. TANK1 is recognized at ~120-140kD in HeLa cells. A lower band of 60-70kD of unknown origin may also be recognized.; ELISA: 0.5-1ug/ml; Optimal dilutions to be determined by the researcher.
• Immunogen: Human Tankyrase protein, expressed as His-tag protein in Baculovirus cells (> 95%)
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-tankyrase antibody

The 3'ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleoprotein telomerase during DNA replication. Telomerase is an unusual RNA-dependent DNA polymerase that uses and RNA component to specify the addition of telomere. The telomeric RNA contains a sequence complementary to TTAGGG. Introduction of telomerase into normal human cells has been shown to extend normal cell life by ~ 20 doubling.

Product Categories/Family for anti-tankyrase antibody

Abs to Enzymes

References

• 1. Smith S et al (1998) Science 282, 1484; Smith S et al (1999) J. Cell Sci. 112, 3649; Chi NW et al (2000) JBC 275, 38437; Cook BD et al (2002) Mol Cell. Biol. 22, 332-342, Meyerson M et al (1997) Cell 90, 785-795

NCBI and Uniprot Product Information

• NCBI GI #: 21356741
• NCBI GeneID: 43095
• NCBI Accession #: NP_651410.1
• NCBI GenBank Nucleotide #: NM_143153.2
• UniProt Accession #: Q9VBP3
• Molecular Weight: 127,945 Da
• NCBI Official Full Name: tankyrase
• NCBI Official Symbol: tankyrase
• NCBI Official Synonym Symbols: BcDNA:LD22548; CG17487; CG4719; DmelCG4719
• NCBI Protein Information: CG4719 gene product from transcript CG4719-RA; tankyrase; CG4719-PA; tankyrase-PA
• UniProt Protein Name: FI03751p
• Protein Family: Tankyrase
• UniProt Gene Name: tankyrase
• UniProt Synonym Gene Names: tankyrase-RA
• UniProt Entry Name: Q9VBP3_DROME