Sheep anti-Human Teneurin-1 Polyclonal Antibody | anti-TENM1 antibody

Teneurin-1 (Ten-1, Tenascin-M1, Ten-m1, Protein Odd Oz/ten-m homolog 1, ODZ1, TNM1)

Cat. Num. AAA6006788

• Gene Names: TENM1; TNM; ODZ1; ODZ3; TNM1; TEN-M1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Teneurin-1; Polyclonal Antibody; Teneurin-1 (Ten-1; Tenascin-M1; Ten-m1; Protein Odd Oz/ten-m homolog 1; ODZ1; TNM1); Anti -Teneurin-1 (Ten-1; anti-TENM1 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Teneurin-1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with sterile PBS.

• Applicable Applications for anti-TENM1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Direct ELISA: 0.5-1ug/ml; Western Blot: 1ug/ml
• Immunogen: Recombinant corresponding to human Teneurin-1 expressed in E. coli (AAFO4723).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TENM1 antibody

Teneurin-1(also Ten-m1, tenascin-M1, and Ten-m/Odz1) is a 250-300kD member of the tenascin family, teneurin subfamily of transmembrane (TM) molecules. It is a covalently-linked homodimer that is expressed in both embryonic and adult neurons, among which are cerebellar granule cells and CA2 pyramidal hippocampal neurons. Teneurin-1 appears to promote neurite outgrowth and mediate cell-to-cell adhesion via homophilic interactions. Human teneurin-1 is a 2725aa type II TM glycoprotein. It contains a 324aa cytoplasmic region (aa1-324) that contains an NLS (aa62-65), plus a 2380aa extracellular domain (ECD). The ECD possesses eight sequential EGF-like domains (aa528-796), five NHL repeats, each of which form a b-propeller (aa1194-1524), and 23 YD/TyrAsp-containing repeats that bind carbohydrates. Cleavage at the N-terminus generates an initial 65kD membrane-spanning fragment, followed by TM cleavage that generates a 45kD cytosolic fragment. C-terminal cleavage generates a short 5kD 41aa peptide (aa2682-2722) termed TCAP-1 that shows bioactivity. One splice variant shows a deletion of (aa1232-1239). Over (aa1-317, human Teneurin-1 shares 96% aa identity with mouse Teneurin-1.

Product Categories/Family for anti-TENM1 antibody

Antibodies; Abs to Extracellular Matrix Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 253970446
• NCBI GeneID: 10178
• NCBI Accession #: NP_001156751.1
• NCBI GenBank Nucleotide #: NM_001163279.1
• UniProt Accession #: Q9UKZ4; Q5JZ17; B2RTR5
• Molecular Weight: 305,011 Da
• NCBI Official Full Name: teneurin-1 isoform 2
• NCBI Official Synonym Full Names: teneurin transmembrane protein 1
• NCBI Official Symbol: TENM1
• NCBI Official Synonym Symbols: TNM; ODZ1; ODZ3; TNM1; TEN-M1
• NCBI Protein Information: teneurin-1; ten-1; teneurin 1; tenascin M1; tenascin-M1; odz, odd Oz/ten-m homolog 1; protein Odd Oz/ten-m homolog 1; odz, odd Oz/ten-m homolog 1(Drosophila); odz (odd Oz/ten-m, Drosophila) homolog 3
• UniProt Protein Name: Teneurin-1
• Protein Family: Teneurin
• UniProt Gene Name: TENM1
• UniProt Synonym Gene Names: ODZ1; TNM1; Ten-1; Ten-m1; IDten-1; Ten-1 ICD; TCPA-1; Ten-1 ECD
• UniProt Entry Name: TEN1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

ODZ1: May function as a cellular signal transducer. Belongs to the tenascin family. Teneurin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: Golgi apparatus; cytoskeleton; nuclear matrix; perinuclear region of cytoplasm; endoplasmic reticulum; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane; nuclear speck; nucleus

Molecular Function: heparin binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: positive regulation of filopodium formation; positive regulation of MAP kinase activity; nervous system development; negative regulation of cell proliferation; positive regulation of actin filament polymerization; transcription, DNA-dependent; regulation of transcription from RNA polymerase III promoter; neuropeptide signaling pathway; immune response; positive regulation of peptidyl-serine phosphorylation