Western Blot (WB)
(Western Blot analysis of ALDH7A1 expression in transfected 293T cell line by ALDH7A1 polyclonal antibody. Lane 1: ALDH7A1 transfected lysate (55.4kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human ALDH7A1 Polyclonal Antibody | anti-ALDH7A1 antibody
ALDH7A1 (Antiquitin-1, Aldehyde Dehydrogenase Family 7 Member A1, Delta1-piperideine-6-carboxylate Dehydrogenease, P6c Dehydrogenase, Alpha-aminoadipic Semialdehyde Dehydrogenase, Alpha-AASA Dehydrogenase, Betaine Aldehyde Dehydrogenase, ATQ1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of ALDH7A1 expression in transfected 293T cell line by ALDH7A1 polyclonal antibody. Lane 1: ALDH7A1 transfected lysate (55.4kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of ALDH7A1 expression in transfected 293T cell line by ALDH7A1 polyclonal antibody. Lane 1: ALDH7A1 transfected lysate (55.4kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]
Uniprot Description
ALDH7A1: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. Defects in ALDH7A1 are the cause of pyridoxine-dependent epilepsy (PDE). PDE is characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride. Belongs to the aldehyde dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.1.8; Carbohydrate Metabolism - pyruvate; Mitochondrial; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tryptophan; EC 1.2.1.3; EC 1.2.1.31; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - ascorbate and aldarate
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; cytosol; nucleus
Molecular Function: L-aminoadipate-semialdehyde dehydrogenase activity; protein binding; aldehyde dehydrogenase (NAD) activity; betaine-aldehyde dehydrogenase activity
Biological Process: sensory perception of sound; glycine betaine biosynthetic process from choline; lysine catabolic process; aldehyde metabolic process
Disease: Epilepsy, Pyridoxine-dependent
Research Articles on ALDH7A1
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Product Notes
The ALDH7A1 aldh7a1 (Catalog #AAA6001079) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALDH7A1 (Antiquitin-1, Aldehyde Dehydrogenase Family 7 Member A1, Delta1-piperideine-6-carboxylate Dehydrogenease, P6c Dehydrogenase, Alpha-aminoadipic Semialdehyde Dehydrogenase, Alpha-AASA Dehydrogenase, Betaine Aldehyde Dehydrogenase, ATQ1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALDH7A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the ALDH7A1 aldh7a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSTLLINQPQ YAWLKELGLR EENEGVYNGS WGGRGEVITT YCPANNEPIA RVRQASVADY EETVKKAREA WKIWADIPAP KRGEIVRQIG DALREKIQVL GSLVSLEMGK ILVEGVGEVQ EYVDICDYAV GLSRMIGGPI LPSERSGHAL IEQWNPVGLV GIITAFNFPV AVYGWNNAIA MICGNVCLWK GAPTTSLISV AVTKIIAKVL EDNKLPGAIC SLTCGGADIG TAMAKDERVN LLSFTGSTQV GKQVGLMVQE RFGRSLLELG GNNAIIAFED ADLSLVVPSA LFAAVGTAGQ RCTTARRLFI HESIHDEVVN RLKKAYAQIR VGNPWDPNVL YGPLHTKQAV SMFLGAVEEA KKEGGTVVYG GKVMDRPGNY VEPTIVTGLG HDASIAHTET FAPILYVFKF KNEEEVFAWN NEVKQGLSSS IFTKDLGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES GSDAWKQYMR RSTCTINYSK DLPLAQGIKF Q. It is sometimes possible for the material contained within the vial of "ALDH7A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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