Rabbit anti-Human, Mouse Acvr1 Polyclonal Antibody | anti-ACVR1 antibody

Acvr1, ID (Acvr1, Acvrlk2, Tgfb1, Activin receptor type-1, Activin receptor type I, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, TSK-7L)

Cat. Num. AAA6000786

• Gene Names: ACVR1; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Acvr1; Polyclonal Antibody; ID (Acvr1; Acvrlk2; Tgfb1; Activin receptor type-1; Activin receptor type I; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; TSK-7L); Anti -Acvr1; anti-ACVR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-ACVR1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: Mouse Acvr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-166 amino acids from the Central region of Mouse Acvr1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Mouse Acvr1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).)

Western Blot (WB)

(Western blot analysis of Acvr1 (arrow) using rabbit polyclonal Mouse Acvr1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Acvr1 gene.)

Western Blot (WB)

(Mouse Acvr1 Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).)

Immunohistochemistry (IHC)

(Mouse Acvr1 Antibody (Center) (AP13796c)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Acvr1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-ACVR1 antibody

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.

Product Categories/Family for anti-ACVR1 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 166235898
• NCBI GeneID: 90
• NCBI Accession #: NP_001104537.1
• NCBI GenBank Nucleotide #: NM_001111067.2
• UniProt Accession #: Q04771
• Molecular Weight: 57,153 Da
• NCBI Official Full Name: activin receptor type-1
• NCBI Official Synonym Full Names: activin A receptor, type I
• NCBI Official Symbol: ACVR1
• NCBI Official Synonym Symbols: FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
• NCBI Protein Information: activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1
• UniProt Protein Name: Activin receptor type-1
• Protein Family: Activin receptor
• UniProt Gene Name: ACVR1
• UniProt Synonym Gene Names: ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I
• UniProt Entry Name: ACVR1_HUMAN

NCBI Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

Uniprot Description

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: apical part of cell; integral to plasma membrane; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; peptide hormone binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: pharyngeal system development; in utero embryonic development; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; negative regulation of signal transduction; germ cell development; patterning of blood vessels; BMP signaling pathway; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; mesoderm formation; transforming growth factor beta receptor signaling pathway; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; determination of left/right symmetry; regulation of ossification; neural crest cell migration; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle

Disease: Fibrodysplasia Ossificans Progressiva