Mouse anti-Human alpha1-antichymotrypsin Monoclonal Antibody | anti-SERPINA3 antibody
mAb anti-Human alpha1-antichymotrypsin
background: alpha1-antichymotrypsin presents in plasma at an average concentration of 0.45mg/mL. It is a protease inhibitor for chymotrypsin-like serine proteinases, such as cathepsin G in neutrophils and chymases in mast cells. The protein is produced in liver and increases during acute phase reaction. Deficiency of this protein can cause liver disease and chronic obstructive pulmonary disease. alpha1-antichymotrypsin is found in neurofibrillary tangles and senile plagues in the brain lesions of Alzheimer's disease.
The alpha1-antichymotrypsin and PSA complex (alpha 1-ACT-PSA) has been used as a biomarker for prostate cancer.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Uniprot Description
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space; extracellular region; intracellular; nucleus
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding
Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Research Articles on SERPINA3
Similar Products
Product Notes
The SERPINA3 serpina3 (Catalog #AAA592365) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mAb anti-Human alpha1-antichymotrypsin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's alpha1-antichymotrypsin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: Detect alpha1- antichymotrypsin (alpha1 ACT) using antibody B7B10 at 1:5000 (0.2mug/mL) dilution. Researchers should empirically determine the suitability of the SERPINA3 serpina3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "alpha1-antichymotrypsin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
