Rat anti-Mouse TLR2 Monoclonal Antibody | anti-TLR2 antibody

TLR2, Mouse, mAb 6C2, biotinylated

Cat. Num. AAA584854

• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
• Synonyms: TLR2; Monoclonal Antibody; Mouse; mAb 6C2; biotinylated; TLR2 Mouse mAb 6C2 Biotin 50ug; anti-TLR2 antibody

• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Form/Format: 0.5ml (100ug/ml) 0.2um filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
• Sequence Length: 785

• Applicable Applications for anti-TLR2 antibody: Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Frozen, Immunofluorescence (IF), Immunoprecipitation (IP)
• Application Notes: The typical starting working dilution is 1:50.; The monoclonal antibody 6C2 can be used for flow cytometry and immuno precipitation. The antibody works in immunofluorescence of fixed RAW cells. The antibody gives only a small inhibition of TLR2 (CD282) ligands in RAW cells. The antibody is not useful for Western blotting.
• Conjugation: Biotin
• Preparation and Storage: Product should be stored at 4 degree C.; Under recommended storage conditions, product is stable for one year.

Related Product Information for anti-TLR2 antibody

Monoclonal antibody 6C2 reacts with mouse Toll-like receptor 2 (TLR2, CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of gram-negative bacteria, several whole gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.

Product Categories/Family for anti-TLR2 antibody

Infectious diseases

References

1. Rharbaoui, F et al; The mycoplasma-derived macrophage-activating 2-kilodalton lipopeptide triggers global immune activation on nasal mucosa-associated lymphoid tissues. Infect Immun 2004, 72: 6978
2. Lan, J et al; Different cytokine response of primary colonic epithelial cells to commensal bacteria. World J Gastoenterol 2005, 11: 3375

NCBI and Uniprot Product Information

• NCBI GI #: 1245680206
• NCBI Official Full Name: TLR2
• Protein Family: Toll-like receptor