Chemical Structure
MDK6620, inhibitor
MDK6620
Purity
0.9991
Synonyms
MDK6620; BTYNB; BTYNB IMP1 Inhibitor; inhibitor
Purity/Purification
0.9991
Form/Format
Solid
Solubility
Ethanol: 4mg/mL (12.94mM)
DMSO: 62mg/mL (200.53mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 62mg/mL (200.53mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
C1=CC=C(C(=C1)C(=O)N)N=CC2=CC=C(S2)Br
Formula
C12H9BrN2OS
CAS Number
304456-62-0
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for MDK6620, inhibitor
MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5uM for IMP1 binding to c-Myc mRNA).MDK6620 downregulates beta-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-kappaB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
Product Categories/Family for MDK6620, inhibitor
References
Mahapatra L, Andruska N, Mao C, et al. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation[J]. Translational Oncology, 2017, 10(5):818-827.
Simon M, Nadine B, Bianca B, et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer[J]. Nucleic Acids Research, 2020(15):15.
Simon M, Nadine B, Bianca B, et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer[J]. Nucleic Acids Research, 2020(15):15.
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Product Notes
The MDK6620 (Catalog #AAA5765155) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MDK6620, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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