Ethynylcytidine, Inhibitor

Ethynylcytidine

Cat. Num. AAA5764264

• Purity: 98.00%
• Synonyms: Ethynylcytidine; ECyD; 3'-C-Ethynylcytidine; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 240mg/mL (898.07mM) Need ultrasonic; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C11H13N3O5
• SMILES: C#C[C@@]([C@@H](CO)O[C@H]1N(C=CC(N)=N2)C2=O)([C@H]1O)O
• CAS Number: 180300-43-0
• In Vitro: In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with a tumor growth inhibition rate on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine on all three administration schedules. In particular, the administration of Ethynylcytidine at 6mg/kg once weekly exhibits a marked tumor-shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment,on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Related Product Information for Ethynylcytidine, inhibitor

Ethynylcytidine is a nucleoside antimetabolite.

Product Categories/Family for Ethynylcytidine, inhibitor

DNA Damage/DNA Repair; Nucleoside Antimetabolite/Analog

References

Shimamoto Y, et al. Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. Jpn J Cancer Res. 2001 Mar;92(3):343-51.