Rhodopsin peptide, Inhibitor

Rhodopsin peptide

Cat. Num. AAA5764166

• Purity: 98.00%
• Synonyms: Rhodopsin peptide; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: >=121.7mg/mL; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C51H88N14O20
• SMILES: CC(C)C(N)C(NC(CO)C(NC(CCCCN)C(NC(C(O)C)C(NC(CCC(O)=O)C(NC(C(O)C)C(NC(CO)C(NC(C(NC(C(C)C)C(NC(C)C(N1C(C(NC(C)C(O)=O)=O)CCC1)=O)=O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O
• In Vitro: In general, the disease-causing protein aggregates with ubiquitin in inclusion bodies disrupt the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins, which leads to photoreceptor apoptosis. Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation when the mutations occur around the chromophore binding pocket of rhodopsin. Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulated activation, rod outer segment instability, and arrestin binding [2][3].
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Related Product Information for Rhodopsin peptide, inhibitor

Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the first events in the perception of light. Rhodopsins belong to the G-protein-coupled receptor family and are extremely sensitive to light. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa.

References

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Malvaez, M., et al., HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A, 2013. 110(7): p. 2647-52.
Rogge, G. A., et al., HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci, 20133(15): p. 6623-32.
Rogge, G. A., et al., HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci, 2013. 33(15): p. 6623-32.
Wells, C.E., et al., Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One, 2018(7): p. e68915.
Wells, C.E., et al., Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One, 2013. 8(7): p. e68915.