Z-WEHD-FMK, inhibitor
Z-WEHD-FMK
Purity
98.00%
Synonyms
Z-WEHD-FMK; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C37H42FN7O10
CAS Number
210345-00-9
Target & IC50
Caspase-1
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Z-WEHD-FMK, inhibitor
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6uM).
Product Categories/Family for Z-WEHD-FMK, inhibitor
References
Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8.
Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8.
Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.
Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.
Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1beta release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936.
Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1beta release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936.
Newman ZL, et al. CA-074Me protection against anthrax lethal toxin. Infect Immun. 2009 Oct;77(10):4327-36.
Newman ZL, et al. CA-074Me protection against anthrax lethal toxin. Infect Immun. 2009 Oct;77(10):4327-36.
Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8.
Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.
Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.
Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1beta release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936.
Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1beta release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936.
Newman ZL, et al. CA-074Me protection against anthrax lethal toxin. Infect Immun. 2009 Oct;77(10):4327-36.
Newman ZL, et al. CA-074Me protection against anthrax lethal toxin. Infect Immun. 2009 Oct;77(10):4327-36.
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Product Notes
The Z-WEHD-FMK (Catalog #AAA5764137) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Z-WEHD-FMK, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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