Isosilybin A, Inhibitor
Isosilybin A
Purity
98.00%
Synonyms
Isosilybin A; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C25H22O10
SMILES
COc(cc([C@H]1Oc(ccc([C@H]([C@H](C2=O)O)Oc3c2c(O)cc(O)c3)c2)c2O[C@@H]1CO)cc1)c1O
CAS Number
142796-21-2
Target & IC50
PPARgamma
ABCA1
Tyrosinase
ABCA1
Tyrosinase
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Isosilybin A, inhibitor
Isosilybin A is a partial PPARgamma agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6uM) and diphenolase (IC50=12.1-44.9uM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
Product Categories/Family for Isosilybin A, inhibitor
References
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.Molecules. 2015 Dec 31;21(1):E55.
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.PLoS One. 2012;7(4):e34630.
Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.Carcinogenesis. 2007 Jul;28(7):1533-42.
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.Molecules. 2015 Dec 31;21(1):E55.
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.PLoS One. 2012;7(4):e34630.
Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.Carcinogenesis. 2007 Jul;28(7):1533-42.
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Product Notes
The Isosilybin A (Catalog #AAA5760531) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Isosilybin A, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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