Euscaphic acid, Inhibitor

Euscaphic acid

Cat. Num. AAA5759884

• Purity: 98.00%
• Synonyms: Euscaphic acid; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• Formula: C30H48O5
• SMILES: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)C[C@@H](O)[C@@H](O)C(C)(C)C5CC[C@@]34C)C2[C@]1(C)O)C(O)=O
• CAS Number: 53155-25-2
• Target & IC50: LDL; NO Synthase; PGE
• In Vitro: Isolated aorta was used to test the anti-contraction effects and the possible mode of action(s) of the EA (1*10 -7 M) and (3*10 -7 M) isolated from Crataegus azarolus var. aronia L. Euscaphic acid showed high anti-contraction effects on norepinephrin (NE), (1*10 -9 -10 -4 M) induced contraction in aortic smooth muscle cells in endothelium-intact, endothelium-denuded, and aortic rings pre-incubated with potassium (K +)-channels blocker (tetraethylammonium, TEA), prostaglandin I 2 (PGI) inhibitor (indomethacin) and cyclic guanosine monophosphate (cGMP) inhibitor (methylene blue). On the other hand, other K 2 channels subtype blockers glibenclamide (GLIB); barium chloride (BaCl) and 4-aminopyridine (4-AP) demonstrated that adenosine triphosphate sensitive K + (K ATP), inwardly rectifying K 2 + (K ir) and voltage-dependent K) channels played no role in anti-contraction induced by EA. Furthermore, the role of L-types calcium (Ca) channels in EA anti-contractile effects on aortic smooth muscle cells was proved, by using the Ca -channel blocker verapamil, as indicated by the production of a potent anti-contraction effect. The results of the current study indicate that the anti-contraction effects of EA may be due to the activation of calcium dependent, K) channels and blocking of L-type Ca ++ channels.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Related Product Information for Euscaphic acid, inhibitor

Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-kappaB activations.

Product Categories/Family for Euscaphic acid, inhibitor

Metabolism; LDL; Immunology/Inflammation; GPCR/G Protein

References

Anti-Contraction Effects of Euscaphic Acid Isolated from Crataegus azarolus var. aronia L on Rats Aortic Smooth Muscle. Adv Life Sci. Technol., 2015, 33.