Tirucallol, Inhibitor
Tirucallol
Purity
98.00%
Synonyms
Tirucallol; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C30H50O
SMILES
[H][C@@]12CCC3=C(CC[C@@]4(C)[C@@H](CC[C@]34C)[C@@H](C)CC\C=C(/C)C)[C@@]1(C)CC[C@H](O)C2(C)C
CAS Number
514-46-5
Target & IC50
PGE
NO Synthase
NOS
NO Synthase
NOS
In Vitro
The effect of CMG neutral extract (25-200microg/ml) and Tirucallol (0.1-100microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Tirucallol, inhibitor
Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
Product Categories/Family for Tirucallol, inhibitor
References
Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells.Exp Biol Med (Maywood). 2009 May;234(5):553-61.
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Product Notes
The Tirucallol (Catalog #AAA5759756) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tirucallol, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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