Structure
Clobenpropit dihydrobromide, Inhibitor
Clobenpropit dihydrobromide
Purity
98.00%
Synonyms
Clobenpropit dihydrobromide; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C14H19Br2ClN4S
SMILES
Br. Br.Clc1ccc(CNC(=N)SCCCc2cnc[nH]2)cc1
CAS Number
145231-35-2
Target & IC50
Human H3LR: ic50 9.44 (pKi)
Rat H3LR: ic50 9.75 (pKi)
H4 receptor: ic50 13nM (Ki)
H2 Receptor: ic50 5.6 (pKi)
Rat H3LR: ic50 9.75 (pKi)
H4 receptor: ic50 13nM (Ki)
H2 Receptor: ic50 5.6 (pKi)
Cell Research
Pancreatic cancer cells (Panc-1, MiaPaCa-2 and AsPC-1).Concentration: 50Mm
In Vitro
Clobenpropit inhibited tumor growth (gemcitabine 294 46 mg vs combination 154 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Clobenpropit dihydrobromide, inhibitor
Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine HR (histamine HLR,pEC50 of 8.07)
Product Categories/Family for Clobenpropit dihydrobromide, inhibitor
References
Mena-Avila E, et al. Clobenpropit, a histamine H receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155.
Mena-Avila E, et al. Clobenpropit, a histamine H receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155.
Esbenshade TA, et al. Two novel and selective nonimidazole histamine H receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96.
Esbenshade TA, et al. Two novel and selective nonimidazole histamine H receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96.
Mena-Avila E, et al. Clobenpropit, a histamine H receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155.
Esbenshade TA, et al. Two novel and selective nonimidazole histamine H receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96.
Esbenshade TA, et al. Two novel and selective nonimidazole histamine H receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305(3):887-96.
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Product Notes
The Clobenpropit dihydrobromide (Catalog #AAA5759236) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Clobenpropit dihydrobromide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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