Structure
AM-0902, inhibitor
AM-0902
Purity
100.00%
Synonyms
AM-0902; inhibitor
Purity/Purification
100.00%
Form/Format
Solid. Powder
Solubility
DMSO: 145mg/mL (391.05mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H15ClN6O2
SMILES
Cn(cn1)c2c1N=CN(Cc1nc(CCc(cc3)ccc3Cl)no1)C2=O
CAS Number
1883711-97-4
Cell Research
On the day of assay, culture media is removed and MDCK cells are incubated for 10 minutes at room temperature (RT) with 50uL of AM-0902 in AM-0902 dilution buffer [HBSS containing 1mM HEPES+0.1mg/mL BSA] at final concentrations (2.0nM to 40uM, 1:3 ratio), followed by another 3 min incubation at RT. The reaction mixture is aspirated, and cells are washed three times with PBS containing 0.1mg/mL BSA. Radioactivity is measured using a TopCount microplate scintillation counter. The activation of TRPA1 is measured by the cellular uptake of radioactive calcium.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for AM-0902, inhibitor
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131nM for rTRPA1 and hTRPA1).
Product Categories/Family for AM-0902, inhibitor
References
Schenkel LB, et al. Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1)Antagonists Demonstrating Potent in Vivo Activity. J Med Chem. 2016 Mar 24;59(6):2794-809.
Similar Products
Product Notes
The AM-0902 (Catalog #AAA5758326) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AM-0902, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
