CTX-0294885 hydrochloride, Inhibitor | CTX-0294885, inhibitor

CTX-0294885 hydrochloride

Cat. Num. AAA5755975

• Purity: 98.00%
• Synonyms: CTX-0294885 hydrochloride; CTX-0294885; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: H2O: 370mg/mL (779.95mM); (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C22H25Cl2N7O
• SMILES: [H]Cl.O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCNCC4)C=C3)=NC=C2Cl
• Target & IC50: Others
• In Vitro: CTX-0294885 is a new type of diaminopyrimidine pyrimidine, showing inhibitory activity against a variety of kinases. CTx-0294885 represents a powerful new reagent that can be used to analyze the kinase group signal network and can promote the development of targeted therapeutic strategies. Large-scale affinity purification based on CTx-0294885, followed by LC-MS/MS, can identify 235 protein kinases in MDA-MB-231 cells, including all members of the AKT family, while other AKT families have not been detected Spectral kinase inhibitor. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase enrichment can increase the number of kinase identifications to 261. Using CTx-0294885 in combination with a broad range of specific inhibitors of three other kinases, 799 high-confidence phosphate sites on 183 kinases can be identified, 10% of which are located in the activation loop and include BMP2K, MELK, HIPK2 and Phosphoric acid sites previously not reported on PRKDC.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for CTX-0294885, inhibitor

CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.

References

Zhang L, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.
Zhang L, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.