Structure

Resorcinolnaphthalein, Inhibitor

Resorcinolnaphthalein

Purity

99.25%

Synonyms

Resorcinolnaphthalein; inhibitor

Ordering
Cat. Num. AAA5754385 For Research Use Only!

Purity/Purification

99.25%

Form/Format

Solid. Powder

Solubility

DMSO: 120mg/mL (313.84mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H14O5

SMILES

Oc1ccc2c(Oc3cc(O)ccc3C22OC(=O)c3cccc4cccc2c34)c1

CAS Number

41307-63-5

Target & IC50

ACE2: ic50 19.5uM (EC50)

In Vitro

resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner. Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10mg/kg, spontaneously hypertensive rats decreased 71+/-9mM Hg and Wistar-Kyoto rats decreased 21+/-8mM Hg; P<0.05). Chronic infusion of the xanthenone (120microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17mM Hg; 2-way ANOVA; P<0.05), whereas it had no effect in Wistar-Kyoto rats. Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats[1].

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Resorcinolnaphthalein, inhibitor

Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5uM).

Product Categories/Family for Resorcinolnaphthalein, inhibitor

Endocrinology/Hormones

References

Hernandez Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7.
Hernandez Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7.

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Product Notes

The Resorcinolnaphthalein (Catalog #AAA5754385) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Resorcinolnaphthalein, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Resorcinolnaphthalein, Inhibitor