Structure
SRT 172 dihydrochloride, Inhibitor | SRT1720, inhibitor
SRT 1720 dihydrochloride [925434-55-5 (free base)]
Purity
98.00%
Synonyms
SRT 172 dihydrochloride; SRT 1720 dihydrochloride [925434-55-5 (free base)]; SRT1720; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C25H25Cl2N7OS
Smiles
Cl.Cl.O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1
Receptor (IC50)
SIRT1: 0.16uM (EC1.5)
SIRT2: 37uM (EC1.5)
SIRT2: 37uM (EC1.5)
Solubility
DMSO: 80mg/mL
Water: 10mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Water: 10mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for SRT1720, inhibitor
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16uM) and shows less potent activities on SIRT2 (EC1.5: 37uM) and SIRT3 (EC1.5: 300uM).
Product Categories/Family for SRT1720, inhibitor
References
1. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450 (7170):712-6
2. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan,Nat Rev Drug Discov. 2012 Jun 1;11 (6):443-61
3. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122 (6):2032-45.
4. Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68 (5):1191-1199.
2. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan,Nat Rev Drug Discov. 2012 Jun 1;11 (6):443-61
3. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122 (6):2032-45.
4. Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68 (5):1191-1199.
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Product Notes
The SRT1720 (Catalog #AAA5751577) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SRT 172 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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