Chemical Structure
8-O-Acetylshanzhiside methyl ester, Inhibitor
8-O-Acetylshanzhiside methyl ester
Purity
98.00%
Synonyms
8-O-Acetylshanzhiside methyl ester; TNF; NF-kappab; VEGFR; Akt; Caspase; inhibitor
Purity/Purification
98.00%
Form/Format
POWDER
CAS Number
57420-46-9
Formula
C19H28O12
Smiles
O=C(OC)C2=CO[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]3[C@@H]2[C@H](O)C[C@]3(C)OC(C)=O
Solubility
DMSO: Soluble
Pathways
Apoptosis; NF-kappab; Angiogenesis; Cytoskeletal Signaling; Apoptosis
Receptor
TNF-alpha; NF-kappab; VEGFR; Akt; Caspase
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
In Solvent: 2 years -80 degree C
Chemical Structure
Chemical Structure
Related Product Information for 8-O-Acetylshanzhiside methyl ester, inhibitor
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-kappaB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood-brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-kappaB signalling pathway.
References
1. ang ZC1, Jiang WL, et al.Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury.Send to Eur J Pharm Sci. 2012 Aug 30; 47(1):124-30.
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Product Notes
The 8-O-Acetylshanzhiside methyl ester (Catalog #AAA5750912) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "8-O-Acetylshanzhiside methyl ester, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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