MMP-11 active protein

MMP-11 (catalytic domain) (human), (recombinant)

Cat. Num. AAA566607

• Purity: >=95% (SDS-PAGE); Purified by multi-step chromatography
• Synonyms: MMP-11; MMP-11 (catalytic domain) (human); (recombinant); MMP-11 active protein

• Host: E Coli
• Purity/Purification: >=95% (SDS-PAGE); Purified by multi-step chromatography
• Form/Format: Liquid. In 50mM TRIS, 5mM CaCl2, 300mM NaCl, 20uM ZnCl2, 0.5% Brij-35, and 30% glycerol

• Source Note: Active Matrix Metalloproteinase-11 (MMP-11, Stromelysin-3) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-11 (Phe98-Ser266) with a C-terminal purification tag. MMPs lacking this domain cannot cleave native collagens; however, activity toward other targets such as gelatin, casein, or peptide substrates is unaffected. It may be an important link between obesity and cancer
• Specific Activity: Due to its unusual substrate preferences [A(A/Q)(N/A)~(L/Y)(T/V/M/R)(R/K), or G(G/A)E~LR5], MMP-11 cleaves MMP peptide substrates extremely slowly (several hours yield very little product). Therefore, the activity of each lot of MMP-11 is verified by digestion of macromolecules
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: For long term storage, store at -80 degree C; Shipping: Shipped on Dry Ice

Related Product Information for MMP-11 active protein

MMP-11 may be a link between obesity and cancer.

Product Categories/Family for MMP-11 active protein

Cellular Analysis; Cell Organelles & Structures; Proteostasis; Proteolysis & Protein Degradation

NCBI and Uniprot Product Information

• UniProt Accession #: P24347
• Molecular Weight: 193kDa
• UniProt Protein Name: Stromelysin-3
• UniProt Gene Name: MMP11
• UniProt Synonym Gene Names: STMY3; SL-3; ST3; MMP-11
• UniProt Entry Name: MMP11_HUMAN

Uniprot Description

MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.

Protein type: Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide; Protease; Secreted

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; proteolysis; negative regulation of fat cell differentiation