LAR active protein

LAR (human), (recombinant)

Cat. Num. AAA566567

• Gene Names: PTPRF; LAR
• Purity: >=90% (SDS-PAGE); Contains no detectable protease, DNase, RNase, or Ser/Thr phosphatase activity
• Synonyms: LAR; LAR (human); (recombinant); LAR active protein

• Host: E Coli
• Purity/Purification: >=90% (SDS-PAGE); Contains no detectable protease, DNase, RNase, or Ser/Thr phosphatase activity
• Form/Format: Liquid. In 50mM TRIS-HCl, pH7.0, containing 100mM sodium chloride, 2mM EDTA, 5mM dithiothreitol, 0.01% Brij 35, and 30% glycerol

• Source Note: Soluble catalytic LAR-D1 domain (350 aa)
• Specific Activity: >=3U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH7.0 and 30 degree C. 20 U can dephosphorylate >95% of phosphotyrosine in 1 nmol protein in 30 minutes
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: For long term storage, store at -80 degree C; Shipping: Shipped on Dry Ice

Related Product Information for LAR active protein

Removes phosphate specifically from tyrosine residues in proteins. Rate of dephosphorylation depends on LAR substrate preference.

Product Categories/Family for LAR active protein

Proteostasis; Posttranslational Modifications

NCBI and Uniprot Product Information

• NCBI GI #: 62088536
• NCBI GeneID: 5792
• UniProt Accession #: P10586; Q5T021; Q5T022; Q5W9G2; Q86WS0; D3DPX6; D3DPX7
• Molecular Weight: 212,879 Da
• NCBI Official Full Name: protein tyrosine phosphatase, receptor type, F isoform 2 variant, partial
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, F
• NCBI Official Symbol: PTPRF
• NCBI Official Synonym Symbols: LAR
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase F; LCA-homolog; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine p
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase F
• Protein Family: Large T antigen
• UniProt Gene Name: PTPRF
• UniProt Synonym Gene Names: LAR; LAR
• UniProt Entry Name: PTPRF_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRF: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: integral to plasma membrane

Molecular Function: heparin binding; protein complex binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: cell migration; cell adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway

Disease: Breasts And/or Nipples, Aplasia Or Hypoplasia Of, 2