Testing Data
(Image: Human cortex, Alzheimer's disease: immunohistochemical staining using amyloid precursor protein-228. Note intense staining of neurofibrillary tangles and senile plaques. Paraffin section)
anti-Human Amyloid Precursor Antibody | anti-APP antibody
Amyloid Precursor Proteins, Monoclonal Antibody, Mouse
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
Amyloid Precursor; Amyloid Precursor Proteins; Monoclonal Antibody; Mouse; anti-APP antibody
Reactivity
Human
Form/Format
Supernatant - Liquid
Applicable Applications for anti-APP antibody
Immunohistochemistry (IHC)
Type Info
Mouse IgG
Immunogen
Prokaryotic recombinant fusion protein corresponding to the extracellular protein of APP between the Kunitz protease inhibitor domain and the beta amyloid region.
Testing Data
(Image: Human cortex, Alzheimer's disease: immunohistochemical staining using amyloid precursor protein-228. Note intense staining of neurofibrillary tangles and senile plaques. Paraffin section)
Testing Data
(Image: Human cortex, Alzheimer's disease: immunohistochemical staining using amyloid precursor protein-228. Note intense staining of neurofibrillary tangles and senile plaques. Paraffin section)
Related Product Information for anti-APP antibody
Alzheimer's disease, the most common cause of dementia in the elderly, exists in both familial and sporadic forms. Genetic studies have identified three genes; beta-amyloid precursor protein (APP), Presenilin 1 and Presenilin 2 which, when mutated, can cause familial forms of Alzheimer's disease. APP and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.
APP-228 has been raised to the extracellular portion of APP between the Kunitz protease inhibitor domain and the beta amyloid region. This region shows the least homology with the APP-like proteins. APP-228 and does not cross-react with APP-like proteins. APP reacts with large pyramidal cells as well as smaller neurons, astrocytes and microglia. APP 228 reacts with late-stage neurofibrillary tangle-bearing neurons, neuritic processes surrounding senile plaques and neuropil threads in gray matter of Alzheimer's disease brain. Unmasking in 1mM EDTA (pH8.0) in a pressure cooker may be required for up to 5 minutes in order for this APP-228 to work optimally.
APP-228 has been raised to the extracellular portion of APP between the Kunitz protease inhibitor domain and the beta amyloid region. This region shows the least homology with the APP-like proteins. APP-228 and does not cross-react with APP-like proteins. APP reacts with large pyramidal cells as well as smaller neurons, astrocytes and microglia. APP 228 reacts with late-stage neurofibrillary tangle-bearing neurons, neuritic processes surrounding senile plaques and neuropil threads in gray matter of Alzheimer's disease brain. Unmasking in 1mM EDTA (pH8.0) in a pressure cooker may be required for up to 5 minutes in order for this APP-228 to work optimally.
Product Categories/Family for anti-APP antibody
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Product Notes
The APP (Catalog #AAA555076) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Amyloid Precursor Proteins, Monoclonal Antibody, Mouse reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Amyloid Precursor can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the APP for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Amyloid Precursor, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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