TECK (CCL25) Recombinant Protein | CCL25 recombinant protein
Human TECK (CCL25) Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant CCL25 is a disulfide-linked homodimeric protein consisting of 128 amino acid residue subunits, and migrates as an approximately 14 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Avoid repeated freeze/thaw cycles.
• thymic progenitor homing and lymphocyte homeostasis are linked via s1p-controlled expression of thymic p-selectin/CCL25 .J. Exp. Med., Apr 2009; 206: 761 - 778.
• CCL25 increases thymopoiesis after androgen withdrawal .Blood, Oct 2008; 112: 3255 - 3263.
• CCL25 and ccl28 promote 4β7-integrin-dependent adhesion of lymphocytes to madcam-1 under shear flow .Am J Physiol Gastrointest Liver Physiol, May 2008; 294: G1257 - G1267.
• activation of ccr9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine .Clin. Cancer Res., Feb 2008; 14: 638 - 645.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Chemokine; Secreted
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine receptor binding; chemokine activity; hormone activity; CCR10 chemokine receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; immune response; chemotaxis; positive regulation of cell-matrix adhesion; inflammatory response; leukocyte migration
Similar Products
Product Notes
The CCL25 ccl25 (Catalog #AAA553326) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR IQEVSGSCNL PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL HHNTQTFQAG PHAVKKLSSG NSKLSSSKFS NPISSSKRNV SLLISANSGL. It is sometimes possible for the material contained within the vial of "TECK (CCL25), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
