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Herpes Simplex Virus-2 gD Recombinant Protein | HSV-2 gD recombinant protein

Recombinant Herpes Simplex Virus-2 gD

Purity
>95%, as determined by SDS-PAGE.
Synonyms
Herpes Simplex Virus-2 gD; Recombinant Herpes Simplex Virus-2 gD; Herpes Simplex Virus-2 gD Recombinant ; hsv-2; hsv2; herpes simplex; hhv; HSV-2 gD recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Specificity
Immunoreactive with sera of infected HSV2 individuals.
Purity/Purification
>95%, as determined by SDS-PAGE.
Form/Format
Sterile solution of 10mM Sodium Carbonate Bicarbonate pH 9.6, 0.1% SDS and 50% glycerol.
Concentration
8 mg/mL (varies by lot)
Sequence Length
393
Host Note
DNA sequence encoding immunodominant fragment of human Herpesvirus-2 Glycoprotein D was expressed in Escherichia Coli.
Endotoxin
Less than 0.1 EU/ug as determined by LAL method.
Preparation and Storage
This protein can be stored in working aliquots at 2-8°C for one month, or at -20°C for 12 months without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Related Product Information for HSV-2 gD recombinant protein
Recombinant HSV-2 gD encodes the immunodominant sequences of the human Herpesvirus Glycoprotein D. This molecule has a calculated mass of approximately 14 kDa. Recombinant HSV2 gD contains an N terminal GST purification tag and migrates as an approximately 43 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
Product Categories/Family for HSV-2 gD recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
NCBI Official Full Name
Envelope glycoprotein D
UniProt Protein Name
Envelope glycoprotein D
UniProt Gene Name
gD
UniProt Synonym Gene Names
US6; gD
UniProt Entry Name
GD_HHV23

Uniprot Description

Function: Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and PVRL1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL

By similarity.

Subunit structure: Homodimer

By similarity. Interacts with host receptor TNFRSF14. Interacts with host receptor PVRL1. Interacts with host receptor PVRL2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C-terminus) with UL11 tegument protein

By similarity. Ref.6 Ref.7

Subcellular location: Virion membrane; Single-pass type I membrane protein

By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs

By similarity.

Sequence similarities: Belongs to the herpesviridae glycoprotein D family.

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Product Notes

The HSV-2 gD gd (Catalog #AAA553145) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Herpes Simplex Virus-2 gD, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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