Exodus-2 recombinant protein

Human Exodus-2 Recombinant

Cat. Num. AAA553133

• Purity: >95%, as determined by SDS-PAGE and HPLC
• Synonyms: Exodus-2; Human Exodus-2 Recombinant; Exodus2; ccl21; Exodus-2 recombinant protein

• Host: E Coli
• Purity/Purification: >95%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant Exodus-2 was lyophilized from a 0.2 um filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.
• Sequence: MAQSLALSLL ILVLAFGIPR TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPSPQKPA QGCRKDRGAS KTGKKGKGSK GCKRTERSQT PKGP
• Sequence Length: 134

• Domain: IL8
• Host Note: Optimized DNA sequence encoding Human Exodus-2 mature chain was expressed in Escherichia Coli.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Native human Exodus-2 is generated by the proteolytic removal of the signal peptide; and propeptide, this molecule has a calculated molecular mass of approximately 12 kDa.; ; Recombinant Exodus-2 is a disulfide-linked homodimeric protein consisting of 112 amino acid residue subunits, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
• Preparation and Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.; Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for Exodus-2 recombinant protein

Exodus-2, which is a member of the family of CC- Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed preferentially in lymph node tissue. Exodus-2 is critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T- cell trafficking through nodal tissue.

Product Categories/Family for Exodus-2 recombinant protein

Cytokines

References

• the cc chemokine thymus-derived chemotactic agent 4 (tca-4, secondary lymphoid tissue chemokine, 6ckine, Exodus-2) triggers lymphocyte function–associated antigen 1–mediated arrest of rolling t lymphocytes in peripheral lymph node high endothelial venules .J. Exp. Med., Jan 2000; 191: 61.