Interleukin-29 Recombinant Protein | IL-29 recombinant protein
Human Interleukin-29 Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant Interleukin-29 (IFN-lambda) is a disulfide-linked monomer protein consisting of 178 amino acid residue subunits, and migrates as an approximately 20kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• ifn-1 (IL-29) inhibits gata3 expression and suppresses th2 responses in human naive and memory t cells .Blood, Jun 2009; 113: 5829 - 5838.
• differentiated human alveolar type ii cells secrete antiviral IL-29 (ifn-1) in response to influenza a infection .J. Immunol., Feb 2009; 182: 1296 - 1304.
• maturing dendritic cells are an important source of IL-29 and il-20 that may cooperatively increase the innate immunity of keratinocytes .J. Leukoc. Biol., May 2008; 83: 1181 - 1193.
• il-28a and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine cmv infection increases colonic il-28a expression .Am J Physiol Gastrointest Liver Physiol, Nov 2005; 289: G960 - G968.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Uniprot Description
IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex
Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding
Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-13 production; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus
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Product Notes
The IL-29 ifnl1 (Catalog #AAA553081) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MAAAWTVVLV TLVLGLAVAG PVPTSKPTTT GKGCHIGRFK SLSPQELASF KKARDALEES LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK VLEAAAGPAL EDVLDQPLHT LHHILSQLQA CIQPQPTAGP RPRGRLHHWL HRLQEAPKKE SAGCLEASVT FNLFRLLTRD LKYVADGNLC LRTSTHPEST. It is sometimes possible for the material contained within the vial of "Interleukin-29, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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