Rabbit SOX10 Polyclonal Antibody | anti-SOX10 antibody

SOX10 Antibody FITC-Conjugated

Cat. Num. AAA544943

• Gene Names: SOX10; DOM; WS4; PCWH; WS2E; WS4C
• Reactivity: Human, Monkey
• Applications: ELISA, Immunoprecipitation, Western Blot
• Synonyms: SOX10; Polyclonal Antibody; SOX10 Antibody FITC-Conjugated; DOM; Dominant megacolon mouse human homolog of; MGC15649; PCWH; SOX 10; SRY (sex determining region Y) box 10; SRY box 10; SRY box containing gene 10; SRY related HMG box gene 10; Transcription factor SOX 10; WS2E; WS4; WS4C antibody; anti-SOX10 antibody

• Host: Rabbit
• Reactivity: Human, Monkey
• Clonality: Polyclonal
• Form/Format: FITC-Conjugated
• Concentration: 0.55-0.75 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 466

• Applicable Applications for anti-SOX10 antibody: ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Dot Blot: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 10-60 on human Transcription Factor SOX-10 protein.
• Expression: Expressed in fetal brain and in adult brain, heart, small intestine and colon.
• Determinant: N-epitope
• Molecular Function: Chromatin binding; Identical protein binding; RNA polymerase II transcription factor binding transcription factor activity invovled in positive regulation of transcription
• Structure: Contains 1 HMG box DNA-binding domain.
• Subcellular Location: Cytoplasm; Nucleus
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-SOX10 antibody

FITC-Conjugated Transcription Factor SOX-10 Antibody N-epitope
Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 5902104
• NCBI GeneID: 6663
• NCBI Accession #: NP_008872.1
• NCBI GenBank Nucleotide #: NM_006941.3
• UniProt Accession #: P56693; Q6FHW7; B4DV62
• Molecular Weight: 31,088 Da
• NCBI Official Full Name: transcription factor SOX-10
• NCBI Official Synonym Full Names: SRY-box 10
• NCBI Official Symbol: SOX10
• NCBI Official Synonym Symbols: DOM; WS4; PCWH; WS2E; WS4C
• NCBI Protein Information: transcription factor SOX-10
• UniProt Protein Name: Transcription factor SOX-10
• Protein Family: Transcription factor
• UniProt Gene Name: SOX10
• UniProt Entry Name: SOX10_HUMAN

NCBI Description

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

Uniprot Description

SOX10: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E). WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C); also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH); also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extrinsic to mitochondrial outer membrane; nucleoplasm; nucleus

Molecular Function: chromatin binding; identical protein binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor binding

Biological Process: anatomical structure morphogenesis; cell maturation; developmental growth; digestive tract morphogenesis; enteric nervous system development; in utero embryonic development; lacrimal gland development; melanocyte differentiation; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; neural crest cell migration; oligodendrocyte differentiation; peripheral nervous system development; positive regulation of gliogenesis; positive regulation of neuroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Disease: Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease; Waardenburg Syndrome, Type 2e; Waardenburg Syndrome, Type 4c