Calcitonin Blocking Peptide | CALCA blocking peptide

Calcitonin Peptide N-epitope

Cat. Num. AAA542923

• Gene Names: CALCA; CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
• Applications: Immunodepletion, Immunocompetition
• Synonyms: Calcitonin; Calcitonin Peptide N-epitope; Alpha CGRP; CALC1; CALCA; Calcitonin related polypeptide alpha; CGRP1; CT; Katacalcin; KC; MGC126648 antibody; CALCA blocking peptide

• Form/Format: Antigenic Blocking Peptide
• Concentration: Quantity: 250 ug; Volume: 100 ul (varies by lot)
• Sequence Length: 93

• Applicable Applications for CALCA blocking peptide: Immunodepletion, Immunocompetition
• Application Notes: Immunocytochemistry: 1:100; Immunofluorescence: 1:100; Immunohistochemistry: 1:100; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 30-80 on human Calcitonin protein.
• Determinant: N-epitope
• Molecular Function: Hormone; Calcitonin receptor binding; Identical protein binding
• Structure: Belongs to calcitonin family; Signal domain
• Subcellular Location: Secreted
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for CALCA blocking peptide

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.Katacalcin is a potent plasma calcium-lowering peptide.

NCBI and Uniprot Product Information

• NCBI GI #: 29608
• NCBI GeneID: 796
• UniProt Accession #: P01258; Q13935; Q13937; Q52LX7; B7ZL39; P06881
• Molecular Weight: 13,898 Da
• NCBI Official Full Name: calcitonin, partial
• NCBI Official Synonym Full Names: calcitonin related polypeptide alpha
• NCBI Official Symbol: CALCA
• NCBI Official Synonym Symbols: CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
• NCBI Protein Information: calcitonin; calcitonin gene-related peptide 1
• UniProt Protein Name: Calcitonin
• Protein Family: Calcitonin
• UniProt Gene Name: CALCA
• UniProt Synonym Gene Names: CALC1; CCP
• UniProt Entry Name: CALC_HUMAN

NCBI Description

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Uniprot Description

CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: cell soma; cytoplasm; extracellular region; extracellular space; nucleus; terminal button

Molecular Function: calcitonin receptor binding; hormone activity; identical protein binding; protein binding; protein complex binding; receptor binding

Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; antibacterial humoral response; antifungal humoral response; cell-cell signaling; cellular protein metabolic process; cytosolic calcium ion homeostasis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; innate immune response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; positive regulation of vasodilation; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; response to yeast; vasculature development; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure