GPCR GPR120 positive control
GPCR GPR120 Positive Control
Functions as a receptor for medium and long chain free fatty acids, signals through a G(q)/G(11)-coupled pathway. Functions as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Description
GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Lipid-binding
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: endocytic vesicle; integral to plasma membrane; plasma membrane
Molecular Function: fatty acid binding; peptide binding; taste receptor activity
Biological Process: cellular response to hormone stimulus; detection of chemical stimulus involved in sensory perception of taste; fat cell differentiation; G-protein coupled receptor protein signaling pathway; hormone secretion; negative regulation of apoptosis; negative regulation of cytokine secretion; negative regulation of inflammatory response
Disease: Body Mass Index Quantitative Trait Locus 10
Research Articles on GPCR GPR120
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Product Notes
The GPCR GPR120 ffar4 (Catalog #AAA542763) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GPCR GPR120 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the GPCR GPR120 ffar4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPCR GPR120, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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