IL1R alpha active protein
IL1R alpha protein
Applications
User optimized
Purity
> 98% pure
Synonyms
IL1R alpha; IL1R alpha protein; IL 1 protein; IL 1; ICIL-1RA protein; Interleukin 1R alpha protein; IL-1R alpha protein; IL1; IL-1RN protein; IRAP protein; IL-1; IL-1 protein; IL-1Ra protein; IL1R alpha active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Lyophilized from 5mM Tris, pH 8.0, with 25mM NaCl. Reconstitute in water to a concentration of 0.1 to 1.0mg/ml. DO NOT VORTEX.
Sequence
Region of IL1R alpha protein corresponding to amino acids MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE.
Applicable Applications for IL1R alpha active protein
User optimized
Protein Type
Recombinant
Biological Significance
Interleukin-1 receptor antagonist (IL1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
Bioactivity
Determined by its ability to inhibit the IL-1alpha stimulation of Mouse D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for IL1R alpha active protein
Purified recombinant Human IL1R alpha protein
Product Categories/Family for IL1R alpha active protein
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Product Notes
The IL1R alpha (Catalog #AAA539552) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IL1R alpha can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL1R alpha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of IL1R alpha protein correspond ing to amino acids MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE. It is sometimes possible for the material contained within the vial of "IL1R alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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