PDGF CC active protein

PDGF CC protein

Cat. Num. AAA539400

• Gene Names: PDGFC; SCDGF; FALLOTEIN
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: PDGF CC; PDGF CC protein; Osteosarcoma-derived Growth Factor protein; Platelet-Derived Growth Factor-CC protein; ODGF protein; Glioma-derived growth factor protein; PCGF protein; GDGF protein; PDGF CC active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of PDGF CC protein corresponding to amino acids MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG.
• Sequence Length: 345

• Applicable Applications for PDGF CC active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells.
• Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for PDGF CC active protein

Purified recombinant Human PDGF CC protein

Product Categories/Family for PDGF CC active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 205830662
• NCBI GeneID: 56034
• Molecular Weight: 20,609 Da
• NCBI Official Full Name: Platelet-derived growth factor C
• NCBI Official Synonym Full Names: platelet derived growth factor C
• NCBI Official Symbol: PDGFC
• NCBI Official Synonym Symbols: SCDGF; FALLOTEIN
• NCBI Protein Information: platelet-derived growth factor C
• UniProt Protein Name: Platelet-derived growth factor C
• UniProt Gene Name: PDGFC
• UniProt Synonym Gene Names: SCDGF; PDGF-C; SCDGF; PDGFC latent form; PDGFC receptor-binding form
• UniProt Entry Name: PDGFC_HUMAN

NCBI Description

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

PDGFC: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q32

Cellular Component: Golgi membrane; extracellular space; cell surface; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding

Biological Process: embryonic development; positive regulation of fibroblast proliferation; organ morphogenesis; central nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; positive regulation of DNA replication