TGF beta 1 active protein
TGF beta 1 protein
Applications
User optimized
Purity
> 98% pure
Synonyms
TGF beta 1; TGF beta 1 protein; TGF beta-1 protein; Differentiation inhibiting factor protein; TGFB1 protein; TGF beta -1 protein; Transforming Growth Factor-beta1 protein; Cartilage-inducing factor protein; TGF beta -1; TGF-1b protein; TGF beta 1 active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Lyophilized from 10mM Sodium Citrate, pH 3.5. Reconstitute in 10 mM Citric Acid pH 3.0.
Sequence
Region of TGF beta 1 protein corresponding to amino acids ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS.
Sequence Length
50
Applicable Applications for TGF beta 1 active protein
User optimized
Protein Type
Recombinant
Biological Significance
The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.
Bioactivity
The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is approximately 0.05 ng/ml, corresponding to a specific activity of approximately 2 x 10^7 units/mg
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
CHO cells
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for TGF beta 1 active protein
Purified recombinant Human TGF beta 1 protein
Product Categories/Family for TGF beta 1 active protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
6,012 Da
NCBI Official Full Name
transforming growth factor b1, partial
UniProt Protein Name
Transforming growth factor b1
UniProt Gene Name
TGF-b1
UniProt Entry Name
Q4LDM3_CAPCA
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Product Notes
The TGF beta 1 tgf-b1 (Catalog #AAA538074) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TGF beta 1 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the TGF beta 1 tgf-b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of TGF beta 1 protein correspond ing to amino acids ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS. It is sometimes possible for the material contained within the vial of "TGF beta 1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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