Rabbit STAT5B Polyclonal Antibody | anti-STAT5B antibody

STAT5B antibody

Cat. Num. AAA536487

• Applications: Western Blot
• Synonyms: STAT5B; Polyclonal Antibody; STAT5B antibody; Polyclonal STAT5B; Anti-STAT5B; signal transducer and activator of transcription 5B; STATB 5; STATB-5; STAT5; anti-STAT5B antibody

• Host: Rabbit
• Clonality: Polyclonal
• Form/Format: Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 786

• Applicable Applications for anti-STAT5B antibody: Western Blot (WB)
• Application Notes: Optimal conditions to be determined by the end user
• Biological Significance: STAT5B is a member of the STAT family of transcription factors. In response to cytokines andgrowth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.
• Cross-Reactivity: Human, Mouse, Rat, Pig, Zebrafish, Chicken, Bovine
• Immunogen: STAT5B antibody was raised in rabbit using the C terminal of STAT5B as the immunogen
• Preparation and Storage: Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western Blot showing STAT5B antibody used at a concentration of 1.0 ug/ml against Fetal Brain Lysate)

Immunohistochemistry (IHC)

(STAT5B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X)

Related Product Information for anti-STAT5B antibody

Affinity purified rabbit polyclonal STAT5B antibody

Product Categories/Family for anti-STAT5B antibody

Signal Transduction; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 165932366
• NCBI GeneID: 20851
• NCBI Accession #: NP_035619
• NCBI GenBank Nucleotide #: NM_011489.3
• UniProt Accession #: P42232; Q541Q5; Q60804; Q8K3Q1; Q9JKM1; Q9R0X8; A2A5D5
• Molecular Weight: 90,002 Da
• NCBI Official Full Name: signal transducer and activator of transcription 5B
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 5B
• NCBI Official Symbol: Stat5b
• NCBI Protein Information: signal transducer and activator of transcription 5B
• UniProt Protein Name: Signal transducer and activator of transcription 5B
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: Stat5b
• UniProt Entry Name: STA5B_MOUSE

Uniprot Description

STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: Oncoprotein; DNA-binding; Transcription factor

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding

Biological Process: positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; positive regulation of multicellular organism growth; female pregnancy; 2-oxoglutarate metabolic process; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; regulation of steroid metabolic process; acute-phase response; T cell homeostasis; Peyer's patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; transcription, DNA-dependent; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; lactation; transcription from RNA polymerase II promoter; response to peptide hormone stimulus; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; progesterone metabolic process; signal transduction; positive regulation of mitotic cell cycle; positive regulation of activated T cell proliferation; fatty acid metabolic process; response to estradiol stimulus; positive regulation of natural killer cell differentiation; regulation of transcription, DNA-dependent; luteinization; positive regulation of cell proliferation; development of secondary male sexual characteristics; creatinine metabolic process; positive regulation of gamma-delta T cell differentiation; regulation of cell adhesion; negative regulation of erythrocyte differentiation; cytokine and chemokine mediated signaling pathway; regulation of multicellular organism growth; citrate metabolic process; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; creatine metabolic process; cellular response to hormone stimulus; positive regulation of lymphocyte differentiation; positive regulation of B cell differentiation; sex differentiation; positive regulation of inflammatory response