Rabbit anti-Human CHRM3 Polyclonal Antibody | anti-CHRM3 antibody

CHRM3 antibody

Cat. Num. AAA535495

• Gene Names: CHRM3; HM3; EGBRS
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: CHRM3 antibody was purified by affinity chromatography.
• Synonyms: CHRM3; Polyclonal Antibody; CHRM3 antibody; Polyclonal CHRM3; Anti-CHRM3; m3 muscarinic receptor; chrm3; muscarinic acetylcholine receptor m3; CHRM 3; m3 muscarinic acetylcholine receptor; muscarinic receptor m3; CHRM -3; muscarinic cholinergic m3 receptor; muscarinic m3 receptor; anti-CHRM3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: CHRM3 antibody was purified by affinity chromatography.
• Form/Format: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 590

• Applicable Applications for anti-CHRM3 antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 5 ug/ml
• Biological Significance: The muscarinic acetylcholine receptor M3, also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor. It is encoded by the human gene CHRM3. The M3 muscarinic receptors are located at many places in the body, e.g., smooth muscles, the endocrine glands, the exocrine glands, as well as the lungs. They are also found in the CNS, where they induce emesis. In general, they cause smooth muscle contraction and increased glandular secretions.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
• Immunogen: CHRM3 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-CHRM3 antibody

Rabbit polyclonal CHRM3 antibody

Product Categories/Family for anti-CHRM3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4502819
• NCBI GeneID: 1131
• NCBI Accession #: NP_000731.1
• NCBI GenBank Nucleotide #: NM_000740.2
• UniProt Accession #: P20309; Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60
• Molecular Weight: 66,128 Da
• NCBI Official Full Name: muscarinic acetylcholine receptor M3
• NCBI Official Synonym Full Names: cholinergic receptor, muscarinic 3
• NCBI Official Symbol: CHRM3
• NCBI Official Synonym Symbols: HM3; EGBRS
• NCBI Protein Information: muscarinic acetylcholine receptor M3
• UniProt Protein Name: Muscarinic acetylcholine receptor M3
• Protein Family: Muscarinic acetylcholine receptor
• UniProt Gene Name: CHRM3
• UniProt Entry Name: ACM3_HUMAN

NCBI Description

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]

Uniprot Description

mAChR M3: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: asymmetric synapse; postsynaptic membrane; integral to plasma membrane; basolateral plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction

Molecular Function: protein binding; receptor activity; drug binding; acetylcholine binding; phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity

Biological Process: cell proliferation; G-protein coupled receptor protein signaling pathway; nervous system development; acetylcholine receptor signaling, muscarinic pathway; smooth muscle contraction; regulation of vascular smooth muscle contraction; energy reserve metabolic process; protein modification process; positive regulation of smooth muscle contraction; signal transduction; regulation of insulin secretion; saliva secretion

Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism