Mouse STAT5B Monoclonal Antibody | anti-STAT5B antibody

STAT5B antibody

• Gene Names: STAT5B; STAT5
• Applications: Dot Blot
• Purity: STAT5B antibody was purified using protein G column chromatography from culture supernatant of hybridomacultured in a medium containing bovine IgG-depleted(approximately 95%) fetal bovine serum.
• Synonyms: STAT5B; Monoclonal Antibody; STAT5B antibody; Monoclonal STAT5B; Anti-STAT5B; Signal transducer and activator of transcription 5B; STAT5; STATB-5; STATB 5; anti-STAT5B antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: STATC321
• Specificity: Human STAT5B
• Purity/Purification: STAT5B antibody was purified using protein G column chromatography from culture supernatant of hybridomacultured in a medium containing bovine IgG-depleted(approximately 95%) fetal bovine serum.
• Form/Format: STAT5B antibody in PBS - 3.0 mM KCl, 1.5 mM KH2 PO4, 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3).
• Concentration: 100 ug/ml (varies by lot)
• Sequence Length: 787

• Applicable Applications for anti-STAT5B antibody: Dot Blot (DB)
• Application Notes: To be optimized by the end user.
• Biological Significance: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
• Cross-Reactivity: Human. Other species not studied
• Biohazard Information: This antibody solution contains sodium azide as a preservative. There is a potential hazard that NaN3 reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice.
• Immunogen: STAT5B antibody was raised in mouse using recombinant Signal Transducer And Activator Of Transcription 5B (Stat5B),
• Preparation and Storage: Store at 2-8 degree C for up to one year. We recommend long term storage at -20 degree C. Avoid repeated freezing and thawing.

Western Blot

(Western Blot analysis of immunized recombinant protein using STAT5B antibody)

Related Product Information for anti-STAT5B antibody

Mouse monoclonal STAT5B antibody

Product Categories/Family for anti-STAT5B antibody

DNA & RNA

NCBI and Uniprot Product Information

• NCBI GI #: 21618344
• NCBI GeneID: 6777
• NCBI Accession #: NP_036580.2
• NCBI GenBank Nucleotide #: NM_012448.3
• UniProt Accession #: P51692; Q8WWS8
• Molecular Weight: 89,866 Da
• NCBI Official Full Name: signal transducer and activator of transcription 5B
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 5B
• NCBI Official Symbol: STAT5B
• NCBI Official Synonym Symbols: STAT5
• NCBI Protein Information: signal transducer and activator of transcription 5B
• UniProt Protein Name: Signal transducer and activator of transcription 5B
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT5B
• UniProt Entry Name: STA5B_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Uniprot Description

STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: Oncoprotein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; protein binding; signal transducer activity; double-stranded DNA binding; chromatin binding; protein phosphatase binding; transcription factor activity; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; lactation; succinate metabolic process; oxaloacetate metabolic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of smooth muscle cell proliferation; T cell differentiation in the thymus; response to lipopolysaccharide; progesterone metabolic process; female pregnancy; positive regulation of multicellular organism growth; fatty acid metabolic process; positive regulation of mitotic cell cycle; positive regulation of activated T cell proliferation; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; luteinization; development of secondary male sexual characteristics; regulation of steroid metabolic process; acute-phase response; creatinine metabolic process; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer's patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; negative regulation of erythrocyte differentiation; regulation of multicellular organism growth; citrate metabolic process; valine metabolic process; development of secondary female sexual characteristics; positive regulation of cell motility; liver development; JAK-STAT cascade; positive regulation of natural killer cell mediated cytotoxicity; creatine metabolic process; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; response to hypoxia; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; positive regulation of inflammatory response

Disease: Growth Hormone Insensitivity With Immunodeficiency