Mouse CAPN9 Monoclonal Antibody | anti-CAPN9 antibody
CAPN9 antibody
FC: 1:100
IHC: 1:150
WB: 1:500-2000
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant CAPN9 protein (Right) or empty vector (Left) detected with CAPN9 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of CAPN9 protein in paraffin embedded Adenocarcinoma of Human endometrium tissue using CAPN9 antibody)
NCBI and Uniprot Product Information
NCBI Description
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CAPN9: Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Calcium-binding; EC 3.4.22.-
Chromosomal Location of Human Ortholog: 1q42.11-q42.3
Cellular Component: cytoplasm
Molecular Function: calcium-dependent cysteine-type endopeptidase activity; calcium ion binding
Biological Process: digestion; proteolysis