Western Blot (WB)
(Western blot analysis of INPP5E expression in HEK293T (A); SP2/0 (B); H9C2 (C) whole cell lysates.)
Rabbit INPP5E Polyclonal Antibody | anti-INPP5E antibody
INPP5E Antibody
Gene Names
INPP5E; CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin
Applications
Western Blot
Purity
Immunogen Affinity Chromatography
Synonyms
INPP5E; Polyclonal Antibody; INPP5E Antibody; Purified Polyclonal INPP5E Antibody; Polyclonal INPP5E antibody; Anti-INPP5E antibody; 72 kDa inositol polyphosphate 5-phosphatase antibody; Phosphatidylinositol 45-bisphosphate 5-phosphatase antibody; Phosphatidylinositol polyphosphate 5-phosphatase type IV antibody; anti-INPP5E antibody
Host
Rabbit
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of INPP5E protein
Purity/Purification
Immunogen Affinity Chromatography
Form/Format
Supplied in liquid form in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3 with 30% Glycerol and 0.01% Sodium Azide
Sequence Length
271
Applicable Applications for anti-INPP5E antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
INPP5E antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human INPP5E as the immunogen
Cross-Reactivity
Mouse, Rat
Preparation and Storage
Store at 4 degree C for short term storage. For long term, aliquot and store at -20 degree C. Avoid repeat freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of INPP5E expression in HEK293T (A); SP2/0 (B); H9C2 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of INPP5E expression in HEK293T (A); SP2/0 (B); H9C2 (C) whole cell lysates.)
Related Product Information for anti-INPP5E antibody
INPP5E is a phosphatidyl inositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidylinositol 4,5-bisphosphate 5-phosphatase. Its intracellular localzation is the primary cilium, a small organelle involved in signal transduction. INPP5E plays a role in hydrolizing PtdInsP3 produced in response to various growth factors such as PDGF. Inactivation of the mouse INPP5E gene decreases primary cilia stability, leading to a multiorgan disorder, including absence of eyes, polydactyly, exencephaly and renal cysts.
Product Categories/Family for anti-INPP5E antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
INPP5E protein
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase E
NCBI Official Symbol
INPP5E
NCBI Official Synonym Symbols
CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin
NCBI Protein Information
phosphatidylinositol polyphosphate 5-phosphatase type IV
Protein Family
NCBI Description
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Research Articles on INPP5E
Similar Products
Product Notes
The INPP5E (Catalog #AAA5316009) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's INPP5E can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the INPP5E for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INPP5E, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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