Western Blot (WB)
(Western blot analysis of SENP5 expression in PC12 (A); Jurkat (B); NIH3T3 (C) whole cell lysates.)
Rabbit SENP5 Polyclonal Antibody | anti-SENP5 antibody
SENP5 Antibody
IHC: 1:100-1:200
Western Blot (WB)
(Western blot analysis of SENP5 expression in PC12 (A); Jurkat (B); NIH3T3 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of SENP5 expression in PC12 (A); Jurkat (B); NIH3T3 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Uniprot Description
SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family.
Protein type: Nucleolus; EC 3.4.22.68; Protease
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus
Molecular Function: protein binding; cysteine-type peptidase activity
Biological Process: cellular protein metabolic process; protein sumoylation; cell division; proteolysis; post-translational protein modification; cell cycle
Research Articles on SENP5
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Product Notes
The SENP5 senp5 (Catalog #AAA5315829) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SENP5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:1000 IHC: 1:100-1:200. Researchers should empirically determine the suitability of the SENP5 senp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SENP5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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